Lymph node targeting is a commonly used strategy for particulate vaccines

particularly for Pickering emulsions. However

extensive research on the internal delivery mechanisms of these emulsions

especially the complex intercellular interactions of deformable Pickering emulsions

has been surprisingly sparse. This gap in knowledge holds significant potential for enhancing vaccine efficacy. This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue. The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study. Various factors impacting the transport process are explored

including local cellular tissue environmental factors and the properties of the Pickering emulsion itself. The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency. Additionally

larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel. This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions. Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery. Importantly

the desired transport efficiency varies depending on the specific application. For instance

while a more rapid transport might be crucial for lymph-node-targeted drug delivery

certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.