Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals

Zheyu Wang; Yupei Jian; Yilei Han; Zhongwang Fu; Diannan Lu; Jianzhong Wu; Zheng Liu

doi:10.1016/j.cjche.2020.06.040

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Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals

Reviews | Updated：2026-01-06

- Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals
- Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals
- 中国化学工程学报（英文版） 2020年28卷第10期页码：2499-2506
- Affiliations：
  
  1. Key Lab of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
  2. Department of Chemical and Environmental Engineering, University of California, Riverside,CA,USA,92521
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.06.040
  中图分类号：
- 纸质出版：2020
- Accepted：
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Zheyu Wang, Yupei Jian, Yilei Han, 等. Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals[J]. 中国化学工程学报（英文版）, 2020,28(10):2499-2506.

Zheyu Wang, Yupei Jian, Yilei Han, Zhongwang Fu, Diannan Lu, Jianzhong Wu, Zheng Liu. Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2499-2506.
Zheyu Wang, Yupei Jian, Yilei Han, 等. Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals[J]. 中国化学工程学报（英文版）, 2020,28(10):2499-2506. DOI： 10.1016/j.cjche.2020.06.040.

Zheyu Wang, Yupei Jian, Yilei Han, Zhongwang Fu, Diannan Lu, Jianzhong Wu, Zheng Liu. Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2499-2506. DOI： 10.1016/j.cjche.2020.06.040.

摘要

Abstract

Enzymatic reactions take place with high chemo-

regio-

and stereo-selectivity

appealing for the direct functionalization of abundant and inexpensive compounds with C-H bonds to make fine chemicals such as high-value intermediates and pharmaceuticals. This review summarizes recent progress in the enzymatic functionalization of C-H bonds with an emphasis on heme enzymes such as cytochrome P450s

chloroperoxidase and unspecific peroxygenases. Specific examples are discussed to elucidate the applications of the molecular and process engineering approaches to overcome the challenges hindering enzymatic C-H functionalization. Also discussed is the recent development of the chemo-enzymatic cascade as an effective way to integrate the power of metal catalysis and enzymatic catalysis for C-H functionalization.

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