Fatty acid hydratase for value-added biotransformation: A review

Yan Zhang; Bekir Engin Eser; Peter Kristensen; Zheng Guo

doi:10.1016/j.cjche.2020.02.008

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Fatty acid hydratase for value-added biotransformation: A review

Reviews | Updated：2026-01-06

- Fatty acid hydratase for value-added biotransformation: A review
- Fatty acid hydratase for value-added biotransformation: A review
- 中国化学工程学报（英文版） 2020年28卷第8期页码：2051-2063
- Affiliations：
  
  1. Department of Engineering, Faculty of Science and Technology, Aarhus University, Gustav wieds vej 10,Aarhus,Denmark,8000
  2. Faculty of Engineering and Science, Department of Chemistry and Bioscience, Aalborg University, Aalborg,Denmark,9220
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.02.008
  中图分类号：
- 纸质出版：2020
- Accepted：
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Yan Zhang, Bekir Engin Eser, Peter Kristensen, 等. Fatty acid hydratase for value-added biotransformation: A review[J]. 中国化学工程学报（英文版）, 2020,28(8):2051-2063.

Yan Zhang, Bekir Engin Eser, Peter Kristensen, Zheng Guo. Fatty acid hydratase for value-added biotransformation: A review[J]. Chinese Journal of Chemical Engineering, 2020, 28(8): 2051-2063.
Yan Zhang, Bekir Engin Eser, Peter Kristensen, 等. Fatty acid hydratase for value-added biotransformation: A review[J]. 中国化学工程学报（英文版）, 2020,28(8):2051-2063. DOI： 10.1016/j.cjche.2020.02.008.

Yan Zhang, Bekir Engin Eser, Peter Kristensen, Zheng Guo. Fatty acid hydratase for value-added biotransformation: A review[J]. Chinese Journal of Chemical Engineering, 2020, 28(8): 2051-2063. DOI： 10.1016/j.cjche.2020.02.008.

摘要

Abstract

The synthesis of hydroxy fatty acids (HFAs) from renewable oil feedstock by addition of water onto C=C bonds has attracted great attention in recent years. Given that selective asymmetric hydration of non-activated C=C bonds has been proven difficult to achieve with chemical catalysts

enzymatic catalysis by fatty acid hydratases (FAHs) presents an attractive alternative approach to produce value-added HFAs with high regio-

enantioand stereospecificity

as well as excellent atom economy. Even though FAHs have just been investigated as a potential biocatalyst for a decade

remarkable information about FAHs in different aspects is available; however

a comprehensive review has not been archived. Herein

we summarize the research progresses on biochemical characterization

structural and mechanistic determination

enzyme engineering

as well as biotechnological application of FAHs. The current challenges and opportunities for an efficient utilization of FAHs in organic synthesis and industrial applications are critically discussed.

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