A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-<i>N</i>-oxide

Funing Sang; Jinpei Huang; Jianhong Xu

doi:10.1016/j.cjche.2020.02.002

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A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide

Catalysis, Kinetics and Reaction Engineering | Updated：2026-01-06

- A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide
- A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide
- 中国化学工程学报（英文版） 2020年28卷第5期页码：1320-1325
- Affiliations：
  
  The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.02.002
  中图分类号：
- 纸质出版：2020
- Accepted：
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Funing Sang, Jinpei Huang, Jianhong Xu. A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide[J]. 中国化学工程学报（英文版）, 2020,28(5):1320-1325. DOI: 10.1016/j.cjche.2020.02.002.

-oxide[J]. 中国化学工程学报, 2020, 28(5): 1320-1325.
Funing Sang, Jinpei Huang, Jianhong Xu. A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide[J]. 中国化学工程学报（英文版）, 2020,28(5):1320-1325. DOI: 10.1016/j.cjche.2020.02.002. DOI：

-oxide[J]. 中国化学工程学报, 2020, 28(5): 1320-1325. DOI： 10.1016/j.cjche.2020.02.002.

摘要

Abstract

3-Methylpyridine-

-oxide is an essential intermediate in the preparation of 2-chloro-5-methylpyridine

which can be used to synthesize nicotine insecticides such as imidacloprid and acetamiprid. The traditional method of production of 3-methylpyridine-

-oxide is catalytic oxidation of 3-methylpyridine in semi-batch reactors. Due to strong exothermic reaction and explosive property of 3-methylpyridine

the reaction efficiency and safety is low using batch technology. Therefore

the development of a safer and efficient 3-methylpyridine-

-oxide production process is very necessary in industrial production. In this paper

microreaction systems were introduced into the preparation of 3-methylpyridine-

-oxide. The comparison of three different methods (traditional semibatch method

co-current microreaction method

and circular microreaction method) showed that the circular microreaction method was the most applicable

with relative higher product yield (~90%)

less side reaction and better reaction control.

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A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide

A circular microreaction method to the safe and efficient synthesis of 3-methylpyridine-N-oxide

DOI：10.1016/j.cjche.2020.02.002

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Abstract

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