Enantioselective esterification of (<i>R,S</i>)-2-(4-methylphenyl) propionic acid <i>via</i> Novozym 435: Optimization and application

Xin Yuan; Lujun Wang; Panliang Zhang; Weifeng Xu; Kewen Tang

doi:10.1016/j.cjche.2019.09.003

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Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application

Catalysis, Kinetics and Reaction Engineering | Updated：2026-01-06

- Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application
- Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application
- 中国化学工程学报（英文版） 2020年28卷第7期页码：1816-1823
- Affiliations：
  
  Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology,Yueyang,China,414006
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2019.09.003
  中图分类号：
- 纸质出版：2020
- Accepted：
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Xin Yuan, Lujun Wang, Panliang Zhang, 等. Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application[J]. 中国化学工程学报（英文版）, 2020,28(7):1816-1823. DOI: 10.1016/j.cjche.2019.09.003.

)-2-(4-methylphenyl) propionic acid
Xin Yuan, Lujun Wang, Panliang Zhang, 等. Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application[J]. 中国化学工程学报（英文版）, 2020,28(7):1816-1823. DOI: 10.1016/j.cjche.2019.09.003. DOI：

)-2-(4-methylphenyl) propionic acid DOI： 10.1016/j.cjche.2019.09.003.

摘要

Abstract

This paper reports on the resolution of (

)-2-(4-methylphenyl) propionic acid (MPPA) enantiomers by enzymatic esterification in organic solvent. Novozym 435 (CALB) has the best catalytic performance compared with other lipases. Of the alcohols screened

-hexanol is the best acyl acceptor and gives the highest enzyme activity and enantioselectivity in

-hexane. Response surface methodology (RSM) was used to evaluate the influence of the factors

such as temperature

enzyme amount

substrate concentration and reaction time on the substrate conversion (

) and enantiomeric excess (ee). The correlation coefficient

for enantiomeric excess and the conversion are 0.9827 and 0.9910

respectively

indicating that can accurately predict the experimental results. By simulation and optimization

the optimal conditions were obtained

involving 600 mmol·L

-1

MPPA concentration (0.60 mmol)

850 mmol·L

-1

hexanol concentration (0.85 mmol)

58 mg enzyme amount

75 ℃ temperature and 4.5 h reaction time

respectively. Under the optimized conditions

the experimental values of conversi

on and enantiomeric excess were 89.34% and 97.84%

respectively

which are in good agreement with the model predictions.

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Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application

Enantioselective esterification of (R,S)-2-(4-methylphenyl) propionic acid via Novozym 435: Optimization and application

DOI：10.1016/j.cjche.2019.09.003

摘要

Abstract

关键词

Keywords

references