Herein

conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide (CTAB

a cationic surfactant) and antibiotic drug (cefixime trihydrate (CMT)) in water and also in occurrence of inorganic salts (NaCl

Na

2

SO

4

and Na

3

PO

4

) over the temperature range of 303.15-323.15 K with an interval of 5 K. In all cases

two critical micelle concentrations (

c

*

) were achieved for the CMT-surfactant system. Addition of CMT drug to CTAB solution decreases the values of

c

*

which indicates the interaction between CMT and CTAB. Both values of

c

*

for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt solution. The values of △

G

m

0

were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising temperature. The obtained outcomes from the △

H

m

0

and △

S

m

0

values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in nature. The thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail.