Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production

Xiaoqiang Jia; Lin Qi; Yaguang Zhang; Xue Yang; Hongna Wang; Fanglong Zhao; Wenyu Lu

doi:10.1016/j.cjche.2016.09.014

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Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production

Fluid Dynamics and Transport Phenomena | Updated：2026-01-06

- Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production
- Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production
- 中国化学工程学报（英文版） 2017年第6期页码：732-740
- Affiliations：
  
  1. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University,Tianjin,China,300072
  2. Key Laboratory of Systems Bioengineering(Tianjin University), Ministry of Education,Tianjin,China,300072
  3. Synthetic Biology Platform, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin,China,300072
- Author bio：
- Funds：
  
  Supported by the National Key Basic Research Program of China (No.2014CB745100), National Natural Science Foundation of China (No.21576197), Tianjin Research Program of Application Foundation and Advanced Technology (No.14JCQNJC06700), Technological Research and Development Programs of the China Offshore Environmental Services Ltd. (CY-HB-10-ZC-055).
- DOI：10.1016/j.cjche.2016.09.014
  中图分类号：
- 纸质出版：2017
- Accepted：
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Xiaoqiang Jia, Lin Qi, Yaguang Zhang, 等. Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production[J]. 中国化学工程学报（英文版）, 2017,(6):732-740.

Xiaoqiang Jia, Lin Qi, Yaguang Zhang, et al. Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production[J]. Chinese Journal of Chemical Engineering, 2017, (6): 732-740.
Xiaoqiang Jia, Lin Qi, Yaguang Zhang, 等. Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production[J]. 中国化学工程学报（英文版）, 2017,(6):732-740. DOI： 10.1016/j.cjche.2016.09.014.

Xiaoqiang Jia, Lin Qi, Yaguang Zhang, et al. Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production[J]. Chinese Journal of Chemical Engineering, 2017, (6): 732-740. DOI： 10.1016/j.cjche.2016.09.014.

摘要

Abstract

This paper describes three-dimensional computational fluid dynamics (CFD) simulations of gas-liquid flow in a novel laboratory-scale bioreactor contained dual ventilation-pipe and double sieve-plate bioreactor (DVDSB) used for sophorolipid (SL) production.To evaluate the role of hydrodynamics in reactor design

the comparisons between conventional fed-batch fermenter and DVDSB on the hydrodynamic behavior are predicted by the CFD methods.Important hydrodynamic parameters of the gas-liquid two-phase system such as the liquid phase velocity field

turbulent kinetic energy and volume-averaged overall and time-averaged local gas holdups were simulated and analyzed in detail.The numerical results were also validated by experimental measurements of overall gas holdups.The yield of sophorolipids was significantly improved to 484 g·L

-1

with a 320 h fermentation period in the new reactor.

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