Natural products from Bacillus subtilis with antimicrobial properties

Tao Wang; Yafei Liang; Mianbin Wu; Zhengjie Chen; Jianping Lin; Lirong Yang

doi:10.1016/j.cjche.2014.05.020

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Natural products from Bacillus subtilis with antimicrobial properties

综述 | Updated：2026-01-06

- Natural products from Bacillus subtilis with antimicrobial properties
- Natural products from Bacillus subtilis with antimicrobial properties
- 中国化学工程学报（英文版） 2015年23卷第4期页码：744-754
- Affiliations：
  
  1. 2 Department of Chemical and Biological Engineering, Zhejiang University,Hangzhou,China,310027
  2. 3 JinhuaPeople's Hospital,Jinhua,China,321000
  3. 4 Zhejiang Key Laboratory of Antifungal Drugs,Taizhou,China,318000
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2014.05.020
  中图分类号：
- 纸质出版：2015
- Accepted：
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Tao Wang, Yafei Liang, Mianbin Wu, 等. Natural products from Bacillus subtilis with antimicrobial properties[J]. 中国化学工程学报（英文版）, 2015,23(4):744-754.

Tao Wang, Yafei Liang, Mianbin Wu, Zhengjie Chen, Jianping Lin, Lirong Yang. Natural products from Bacillus subtilis with antimicrobial properties[J]. Chin.J.Chem.Eng., 2015, 23(4): 744-754.
Tao Wang, Yafei Liang, Mianbin Wu, 等. Natural products from Bacillus subtilis with antimicrobial properties[J]. 中国化学工程学报（英文版）, 2015,23(4):744-754. DOI： 10.1016/j.cjche.2014.05.020.

Tao Wang, Yafei Liang, Mianbin Wu, Zhengjie Chen, Jianping Lin, Lirong Yang. Natural products from Bacillus subtilis with antimicrobial properties[J]. Chin.J.Chem.Eng., 2015, 23(4): 744-754. DOI： 10.1016/j.cjche.2014.05.020.

摘要

Abstract

Bacillus subtilis produces many chemically-diverse secondary metabolites of interest to chemists and biologists. Based on this

this review gives a detailed overview of the natural components produced by B. subtilis including cyclic lipopeptides

polypeptides

proteins (enzymes)

and non-peptide products. Their structures

bioactive activities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites

isolation and purification

as well as the overproduction of bioactive compounds from B. subtilis by metabolic engineering

were also highlighted. Systematically exploring biosynthetic routes and the functions of secondary metabolites from B. subtilis may not only be beneficial in improving yields of the products

but also in helping themto be used in food industry and publicmedical service on a large-scale.

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