Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems

Mehdi Ardjmand; Mehrdad Mirzajanzadeh; Fatemeh Zabihi

doi:10.1016/S1004-9541(14)60073-2

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Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems

催化、动力学与反应工程 | Updated：2026-01-06

- Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems
- Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems
- 中国化学工程学报（英文版） 2014年第5期页码：549-5581004-954160073-2
- Affiliations：
  
  1. Islamic Azad University, South Tehran Branch, Graduate Faculty, Department of Chemical Engineering, Tehran,Iran
  2. 2 Islamic Azad University, Science and Research Branch, Department of Chemical Engineering, Tehran,Iran
  3. 3 Islamic Azad University, Ayatollah Amoli Branch, Department of Chemical Engineering, Amol,Iran
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(14)60073-2
  中图分类号：
- 纸质出版：2014
- Accepted：
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Mehdi Ardjmand, Mehrdad Mirzajanzadeh, Fatemeh Zabihi. Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems[J]. 中国化学工程学报（英文版）, 2014,(5):549-5581004-954160073-2.

Mehdi Ardjmand, Mehrdad Mirzajanzadeh, Fatemeh Zabihi. Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems[J]. Chinese Journal of Chemical Engineering, 2014, (5): 549-5581004-954160073-2.
Mehdi Ardjmand, Mehrdad Mirzajanzadeh, Fatemeh Zabihi. Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems[J]. 中国化学工程学报（英文版）, 2014,(5):549-5581004-954160073-2. DOI： 10.1016/S1004-9541(14)60073-2.

Mehdi Ardjmand, Mehrdad Mirzajanzadeh, Fatemeh Zabihi. Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems[J]. Chinese Journal of Chemical Engineering, 2014, (5): 549-5581004-954160073-2. DOI： 10.1016/S1004-9541(14)60073-2.

摘要

Abstract

A dynamic experimental set-up was utilized to measure ibuprofen solubility in supercritical CO

at the pressure range of 8-13 MPa and the temperatures of 308

313 and 318 K. Mole fraction values varied from 0.015×10

-3

to 3.261×10

-3

and correlated by using seven different semi empirical equations of state (Bartle

Modified Bartle

Mendez-Teja

Modified Mendez-Teja

Kumar-Johnson

Sung-shim and Gordillo) as well as seven cubic equations of state (van der Waals

Redlich-Kwong

Soave-Redlich-Kwong

Peng-Robinson

Stryjek-Vera

Patel-Teja-Valderana and Pazuki). Single and twin-parametric van der Walls mixing rules (vdW1

vdW2) were applied in order to estimate the supercritical solution properties. The physicochemical properties were also obtained using Joback

Lydersen and Ambrose methods. Absolute average relatives deviation (AARD) were calculated and compared for all the correlating systems. Results showed that among the cubic equations of state (EOSs) the Pazuki equation (AARD 19.85% using vdW1 and AARD 8.79% using vdW2) and SRK equation (AARD 19.20% using vdW1 and AARD 10.03% using vdW2) predicted the ibuprofen solubility in supercritical CO

with the least error in comparison to the others. Among the semi-empir

ical EOSs the most desirable deviation (AARD10%) was obtained by using Modified Bartle and Modified Mendez-Teja equations in all the studied temperatures.

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