Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process

李文锋; 刘贵金; 李黎仙; 伍娟; 吕扬效; 江燕斌

doi:10.1016/S1004-9541(11)60251-6

Your Location：

Home >

Browse articles >

Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process

Updated：2026-01-06

- Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process
- Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process
- 中国化学工程学报（英文版） 2012年20卷第4期页码：803-813
- Affiliations：
  
  1. Star Lake Bioscience Co., Inc.,Zhaoqing,China,526040
  2. School of Chemistry and Chemical Engineering, South China University of Technology,Guangzhou,China,510640
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (21076084);the Fundamental Research Funds for the Central Universities (2011ZZ0006);the Open Project Program of Provincial Key Laboratory of Green Processing Technology and Product Safety of Natural Products
- DOI：10.1016/S1004-9541(11)60251-6
  中图分类号：
- 纸质出版：2012
- Accepted：
Scan QR Code
李文锋, 刘贵金, 李黎仙, 等. Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process[J]. 中国化学工程学报（英文版）, 2012,20(4):803-813.

LI Wenfeng, LIU Guijin, LI Lixian, WU Juan, LÜ Yangxiao, JIANG Yanbin. Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process[J]. Chin.J.Chem.Eng., 2012, 20(4): 803-813.
李文锋, 刘贵金, 李黎仙, 等. Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process[J]. 中国化学工程学报（英文版）, 2012,20(4):803-813. DOI： 10.1016/S1004-9541(11)60251-6.

LI Wenfeng, LIU Guijin, LI Lixian, WU Juan, LÜ Yangxiao, JIANG Yanbin. Effect of Process Parameters on Co-precipitation of Paclitaxel and Poly(L-lactic Acid) by Supercritical Antisolvent Process[J]. Chin.J.Chem.Eng., 2012, 20(4): 803-813. DOI： 10.1016/S1004-9541(11)60251-6.

摘要

Abstract

Paclitaxel(PTX) is an effective anticancer drug with poor solubility in water.Recently

much effort has been devoted into alternative formulations of PTX for improving its aqueous solubility.In this study

PTX and poly(L-lactic acid)(PLLA) were co-precipitated by a supercritical antisolvent(SAS) process using dichloromethane(DCM) and the mixtures of DCM/ethanol(EtOH) or DCM/dimethyl sulfoxide(DMSO) as the solvent

with super-critical carbon dioxide as the antisolvent.The effects of solvent

solvent ratio

temperature

pressure

polymer concentration and solution flow rate on particle morphology

mass median diameter(

) and PTX loading were investigated using single-factor method.The particle samples were characterized using X-ray diffraction(XRD)

scanning electron microscopy(SEM)

laser diffraction particle size analyzer and high pressure liquid chromatography(HPLC).XRD results indicate that the micronized PTX is dispersed into the PLLA matrix in an amorphous form.SEM indicates that the solvent and the solvent ratio have great effect on the particle morphologies

and particle morphology is good at the volume ratio of DCM/EtOH of 50/50.For the mixed DCM/EtOH solvent

increases with the increase of the temperature

pressure

PLLA concentration and solution flow rate

and PTX loading increases with pressure.Suitable operating conditions for the experimental system are as follows:DCM/EtOH 50/50(by volume)

35℃

10-12 MPa

PLLA concentrat

ion of 5 g·L

-1

and solution flow rate of 0.5 ml·min

-1

关键词

Keywords

references

浏览量

1557

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Selective precipitation of multiple metals and the construction of a magnesium precursor solution from water-quenched titanium slag leachate

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

Synthesis of spinel ferrite and its role in the removal of free fatty acids from deteriorated vegetable oil

CO2 capture by double metal modified CaO-based sorbents from pyrolysis gases

Cobalt catalysts for Fischer-Tropsch synthesis: The effect of support, precipitant and pH value