Issues in Freeze Drying of Aqueous Solutions

王维; 陈墨; 陈国华

doi:10.1016/S1004-9541(11)60218-8

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Issues in Freeze Drying of Aqueous Solutions

香港科技大学化学与生物分子工程系戈登·麦凯教授退休纪念专刊 | Updated：2026-01-06

- Issues in Freeze Drying of Aqueous Solutions
- Issues in Freeze Drying of Aqueous Solutions
- 中国化学工程学报（英文版） 2012年20卷第3期页码：551-559
- Affiliations：
  
  1. College of Life Science, Dalian Nationalities University,Dalian,China,116600
  2. Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology,Hong Kong,China
  3. Department of Chemical Engineering, Dalian University of Technology,Dalian,China,116024
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China(21076042);Research Grants Council of Hong Kong SAR (RGC 600704)
- DOI：10.1016/S1004-9541(11)60218-8
  中图分类号：
- 纸质出版：2012
- Accepted：
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王维, 陈墨, 陈国华. Issues in Freeze Drying of Aqueous Solutions[J]. 中国化学工程学报（英文版）, 2012,20(3):551-559.

WANG Wei, CHEN Mo, CHEN Guohua. Issues in Freeze Drying of Aqueous Solutions[J]. , 2012, 20(3): 551-559.
王维, 陈墨, 陈国华. Issues in Freeze Drying of Aqueous Solutions[J]. 中国化学工程学报（英文版）, 2012,20(3):551-559. DOI： 10.1016/S1004-9541(11)60218-8.

WANG Wei, CHEN Mo, CHEN Guohua. Issues in Freeze Drying of Aqueous Solutions[J]. , 2012, 20(3): 551-559. DOI： 10.1016/S1004-9541(11)60218-8.

摘要

Abstract

Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry.The increased importance of the process is gaining a worldwide interest of research.A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism.Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying

material science and mechanisms of heat and mass transfer.This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades.The important issues of the process are analyzed.

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