Supercritical Antisolvent-based Technology for Preparation of Vitamin D<sub>3</sub> Proliposome and Its Characteristics

夏菲; 金鹤阳; 赵亚平; 郭新秋

doi:10.1016/S1004-9541(11)60089-X

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Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics

Updated：2026-01-06

- Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics
- Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics
- 中国化学工程学报（英文版） 2011年19卷第6期页码：1039-1046
- Affiliations：
  
  1. College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University,Shanghai,China,200240
  2. Instrumental Analysis Center, Shanghai Jiao Tong University,Shanghai,China,200240
- Author bio：
- Funds：
  
  Supported by the National High Technology Research and Development Program of China (2007AA10Z350);the National Natural Science Foundation of China (20976103)
- DOI：10.1016/S1004-9541(11)60089-X
  中图分类号：
- 纸质出版：2011
- Accepted：
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夏菲, 金鹤阳, 赵亚平, 等. Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics[J]. 中国化学工程学报（英文版）, 2011,19(6):1039-1046. DOI: 10.1016/S1004-9541(11)60089-X.

Proliposome and Its Characteristics[J]. , 2011, 19(6): 1039-1046.
夏菲, 金鹤阳, 赵亚平, 等. Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics[J]. 中国化学工程学报（英文版）, 2011,19(6):1039-1046. DOI: 10.1016/S1004-9541(11)60089-X. DOI：

Proliposome and Its Characteristics[J]. , 2011, 19(6): 1039-1046. DOI： 10.1016/S1004-9541(11)60089-X.

摘要

Abstract

Vitamin D

(VD

) proliposomes (VDP)

consisted of hydrogenated phosphatidycholine (HPC) and VD

were prepared using supercritical anti-solvent technology (SAS). The effects of operation conditions (temperature

pressure and components) on the VD

loading in VDP were studied. At the optimum conditions of pressure of 8.0 MPa

temperature of 45℃

and the mass ratio of 15.0% between VD

and HPC

the VD

loading reached 12.89%. VD

liposomes (VDL) were obtained by hydrating VDP and the entrapment efficiency of VD

in VDL reached 98.5%. The morphology and structure of VDP and VDL were characterized by SEM (scanning electron microscope)

TEM (transmission electron microscope) and XRD (X-ray diffractometer). The structure of VD

nanoparticles in HPC matrix was formed. The size of VDL with an average diameter of about 1μm was determined by dynamic light scattering instrument (DLS). The results indicated that VDP can be made by SAS and VDL with high entrapment efficiency can be formed easily via the hydration of VDP.

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Supercritical Antisolvent-based Technology for Preparation of Vitamin D3 Proliposome and Its Characteristics

Supercritical Antisolvent-based Technology for Preparation of Vitamin D3 Proliposome and Its Characteristics

DOI：10.1016/S1004-9541(11)60089-X

摘要

Abstract

关键词

Keywords

references

Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics

Supercritical Antisolvent-based Technology for Preparation of Vitamin D₃ Proliposome and Its Characteristics