Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by <i>Candida tropicalis</i>

王普; 苏会贞; 孙立明; 何军邀; 吕亚萍

doi:10.1016/S1004-9541(11)60087-6

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Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis

Updated：2026-01-06

- Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis
- Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis
- 中国化学工程学报（英文版） 2011年19卷第6期页码：1028-1032
- Affiliations：
  
  1. College of Pharmaceutical Science, Zhejiang University of Technology,Hangzhou,China,310014
  2. Zhejiang Pharmaceutical College,Ningbo,China,315100
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (21076193);Foundation of Zhejiang Key Developing Discipline of Pharmacy (20100609)
- DOI：10.1016/S1004-9541(11)60087-6
  中图分类号：
- 纸质出版：2011
- Accepted：
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王普, 苏会贞, 孙立明, 等. Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis[J]. 中国化学工程学报（英文版）, 2011,19(6):1028-1032. DOI: 10.1016/S1004-9541(11)60087-6.

[J]. , 2011, 19(6): 1028-1032.
王普, 苏会贞, 孙立明, 等. Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis[J]. 中国化学工程学报（英文版）, 2011,19(6):1028-1032. DOI: 10.1016/S1004-9541(11)60087-6. DOI：

[J]. , 2011, 19(6): 1028-1032. DOI： 10.1016/S1004-9541(11)60087-6.

摘要

Abstract

(

)-3

5-bistrifluoromethylphenyl ethanol is a key chiral intermediate for the synthesis of NK-1 receptor antagonists. Enantioselective synthesis of (

)-3

5-bistrifluoromethylphenyl ethanol was successfully performed in high enantiomeric excess (e.e.) through asymmetric reduction of 3

5-bis(trifluoromethyl) acetophenone catalyzed by

Candida tropicalis

104 cells. The influence of some key reaction parameters such as substrate concentration

co-substrate and its concentration

biomass and reaction time was examined

respectively. The results showed that these factors obviously influence the yield

but the optical purity of the prepared product remains intact. The optimum conditions for the preparation of (

)-3

5-bistrifluoromethylphenyl ethanol were found to be as follows: substrate concentration 50 mmol·L

-1

; 50 g·L

-1

of maltose as co-substrate; wet cell concentration 300 g·L

-1

; reaction for 30 h. Under above optimal conditions

the maximum yield for (

)-3

5-bistrifluoromethylphenyl ethanol reached 70.3% with 100% of product e.e.

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Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis

Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis

DOI：10.1016/S1004-9541(11)60087-6

摘要

Abstract

关键词

Keywords

references