Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

罗宁; 卢英妹; 江燕斌

doi:10.1016/S1004-9541(11)60021-9

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Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

Updated：2026-01-06

- Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide
- Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide
- 中国化学工程学报（英文版） 2011年19卷第4期页码：558-564
- Affiliations：
  
  1. Star Lake Bioscience Co., Inc.,Zhaoqing,China,526040
  2. School of Chemistry and Chemical Engineering, South China University of Technology,Guangzhou,China,510640
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (21076084, 20676046);the Fundamental Research Funds for the Central Universities (2011ZZ0006)
- DOI：10.1016/S1004-9541(11)60021-9
  中图分类号：
- 纸质出版：2011
- Accepted：
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罗宁, 卢英妹, 江燕斌. Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide[J]. 中国化学工程学报（英文版）, 2011,19(4):558-564.

LUO Nin, LU Yingmei, JIANG Yanbin. Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide [J]. , 2011, 19(4): 558-564.
罗宁, 卢英妹, 江燕斌. Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide[J]. 中国化学工程学报（英文版）, 2011,19(4):558-564. DOI： 10.1016/S1004-9541(11)60021-9.

LUO Nin, LU Yingmei, JIANG Yanbin. Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide [J]. , 2011, 19(4): 558-564. DOI： 10.1016/S1004-9541(11)60021-9.

摘要

Abstract

Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature

pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases

the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng

Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters

and

can predict paclitaxel solubility for the best fit of experimental data.

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