Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants

唐课文; 苗家兵; 周涛; 刘永兵

doi:10.1016/S1004-9541(09)60227-5

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Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants

评述 | Updated：2026-01-06

- Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants
- Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants
- 中国化学工程学报（英文版） 2011年19卷第3期页码：397-403
- Affiliations：
  
  College of Chemistry and Chemical Engineering, Central South University,Changsha,China,410083
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(09)60227-5
  中图分类号：
- 纸质出版：2011
- Accepted：
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唐课文, 苗家兵, 周涛, 等. Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants[J]. 中国化学工程学报（英文版）, 2011,19(3):397-403.

-CD Derivatives Extractants[J]. Chinese Journal of Chemical Engineering, 2011, 19(3): 397-403.
唐课文, 苗家兵, 周涛, 等. Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants[J]. 中国化学工程学报（英文版）, 2011,19(3):397-403. DOI： 10.1016/S1004-9541(09)60227-5.

-CD Derivatives Extractants[J]. Chinese Journal of Chemical Engineering, 2011, 19(3): 397-403. DOI： 10.1016/S1004-9541(09)60227-5.

摘要

This paper deals with the enantioseparation of phenylsuccinic acid(H

A)enantiomers by liquid-liquid reactive extraction using β-CD derivatives as aqueous selectors.Cyclodextrin and its derivatives can interact with guest molecules selectively to form complexes with different stabilities.Cyclodextrin derivatives are not soluble in organic liquids

but highly soluble in water.In this work

hydroxypropyl-β-cyclodextrin(HP-β-CD)

hydroxyethylβ-cyclodextrin(HE-β-CD)and methyl-β-cyclodextrin(Me-β-CD)were selected as chiral selectors in aqueous phase for the reactive extraction of phenylsuccinic acid enantiomers from organic phase to aqueous phase.The results show that the efficiency of the extraction depends

often strongly

on a number of process variables

including the types of organic solvents and β-CD derivatives

the concentrations of the extractants and H

A enantiomers

pH and temperature.HP-β-CD

HE-β-CD and Me-β-CD have stronger recognition abilities for R-phenylsuccinic acid than for S-phenylsuccinic acid.Among the three kinds of β-CD derivatives

HP-β-CD has the strongest separation ability. Excellent enantioseparation was achieved under the optimal conditions of pH of 2.5 and temperature of 5℃ with a maximum enantioselectivity(a)of 2.38.Reactive extraction of enantiomers with hydrophilic β-CD derivatives is of strong chiral separation ability and can be hopeful for separations of various enantiomers at a large-scale.

Abstract

This paper deals with the enantioseparation of phenylsuccinic acid(H

A)enantiomers by liquid-liquid reactive extraction usingβ-CD derivatives as aqueous selectors.Cyclodextrin and its derivatives can interact with guest molecules selectively to form complexes with different stabilities.Cyclodextrin derivatives are not soluble in organic liquids

but highly soluble in water.In this work

hydroxypropyl-β-cyclodextrin(HP-β-CD)

hydroxyethyl β-cyclodextrin(HE-β-CD)and methyl-β-cyclodextrin(Me-β-CD)were selected as chiral selectors in aqueous phase for the reactive extraction of phenylsuccinic acid enantiomers from organic phase to aqueous phase.The results show that the efficiency of the extraction depends

often strongly

on a number of process variables

including the types of organic solvents and β-CD derivatives

the concentrations of the extractants and H

A enantiomers

pH and temperature.HP-β-CD

HE-β-CD and Me-β-CD have stronger recognition abilities for R-phenylsuccinic acid than for S-phenylsuccinic acid.Among the three kinds of β-CD derivatives

HP-β-CD has the strongest separation ability. Excellent enantioseparation was achieved under the optimal conditions of pH of 2.5 and temperature of 5℃ wi

th a maximum enantioselectivity(a)of 2.38.Reactive extraction of enantiomers with hydrophilic β-CD derivatives is of strong chiral separation ability and can be hopeful for separations of various enantiomers at a large-scale.

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