Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435

尹春华; 张聪; 高明

doi:10.1016/S1004-9541(09)60189-0

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Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435

Updated：2026-01-06

- Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435
- Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435
- 中国化学工程学报（英文版） 2011年19卷第1期页码：135-139
- Affiliations：
  
  Department of Biological Science and Technology, School of Applied Science, University of Science and Technology Beijing,Beijing,China,100083
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(09)60189-0
  中图分类号：
- 纸质出版：2011
- Accepted：
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尹春华, 张聪, 高明. Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435[J]. 中国化学工程学报（英文版）, 2011,19(1):135-139.

YIN Chunhua, ZHANG Cong, GAO Ming. Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435[J]. , 2011, 19(1): 135-139.
尹春华, 张聪, 高明. Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435[J]. 中国化学工程学报（英文版）, 2011,19(1):135-139. DOI： 10.1016/S1004-9541(09)60189-0.

YIN Chunhua, ZHANG Cong, GAO Ming. Enzyme-catalyzed Synthesis of Vitamin E Succinate Using a Chemically Modified Novozym-435[J]. , 2011, 19(1): 135-139. DOI： 10.1016/S1004-9541(09)60189-0.

摘要

Abstract

Vitamin E succinate was synthesized in organic solvents using a modified Novozym-435 as catalyst.In order to improve the catalytic performance of Novozym-435

the enzyme was modified using acetic anhydride

propionic anhydride and succinic anhydride separately.We found that both the hydrolytic activity and the thermal stability of the modified Novozym-435 were enhanced compared with the unmodified enzyme.The modified Novozym-435 catalysts were used to synthesize the succinate derivative of vitamin E.Compared with the native Novozym-435

the catalytic activity of the modified novozym-435 in promoting the synthesis of vitamin E succinate was dramatically increased

with the novozym-435 modified with succinic anhydride(N435-S)as the most active catalyst.Conditions for the synthesis of vitamin E succinate were also optimized.A mixture of

tert

-butanol and DMSO(volume ratio of 2:3)was the most suitable medium for the reaction

whereas the appropriate molar ratio of vitamin E to succinic anhydride and reaction temperature were 1:5 and 40℃

respectively.Under these reaction conditions

the yield of vitamin E succinate reached 94.4%.N435-S could be reused for five batches.

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