On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter

王建林; 赵利强; 于涛

doi:10.1016/S1004-9541(08)60351-1

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On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter

Updated：2026-01-06

- On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter
- On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter
- 中国化学工程学报（英文版） 2010年18卷第2期页码：258-264
- Affiliations：
  
  School of Information Science and Technology, Beijing University of Chemical Technology,Beijing,China,100029
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(08)60351-1
  中图分类号：
- 纸质出版：2010
- Accepted：
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王建林, 赵利强, 于涛. On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter[J]. 中国化学工程学报（英文版）, 2010,18(2):258-264.

WANG Jianlin, ZHAO Liqiang, YU Tao. On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter[J]. , 2010, 18(2): 258-264.
王建林, 赵利强, 于涛. On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter[J]. 中国化学工程学报（英文版）, 2010,18(2):258-264. DOI： 10.1016/S1004-9541(08)60351-1.

WANG Jianlin, ZHAO Liqiang, YU Tao. On-line Estimation in Fed-batch Fermentation Process Using State Space Model and Unscented Kalman Filter[J]. , 2010, 18(2): 258-264. DOI： 10.1016/S1004-9541(08)60351-1.

摘要

Abstract

On-line estimation of unmeasurable biological variables is important in fermentation processes

directly influencing the optimal control performance of the fermentation system as well as the quality and yield of the targeted product.In this study

a novel strategy for state estimation of fed-batch fermentation process is proposed.By combining a simple and reliable mechanistic dynamic model with the sample-based regressive measurement model

a state space model is developed.An improved algorithm

swarm energy conservation particle swarm optimization(SECPSO)

is presented for the parameter identification in the mechanistic model

and the support vector machines(SVM) method is adopted to establish the nonlinear measurement model.The unscented Kalman filter(UKF) is designed for the state space model to reduce the disturbances of the noises in the fermentation process.The proposed on-line estimation method is demonstrated by the simulation experiments of a penicillin fed-batch fermentation process.

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