Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate

Dai Zhang; Xiaofeng Xu; Yueqiang Cao; Wei Li; Jinghong Zhou; Xinggui Zhou

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Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate

Updated：2026-01-06

- Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate
- Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate
- 中国化学工程学报（英文版） 2025年81卷第5期页码：171-181
- Affiliations：
  
  1. State Key Laboratory of Chemical Engineering, East China University of Science and Technology,Shanghai,China,200237
  2. School of Chemical Engineering, East China University of Science and Technology,Shanghai,China,200237
  3. School of Resources and Environmental Engineering, East China University of Science and Technology,Shanghai,China,200237
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2025
- Accepted：
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Dai Zhang, Xiaofeng Xu, Yueqiang Cao, 等. Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate[J]. 中国化学工程学报（英文版）, 2025,81(5):171-181.

Dai Zhang, Xiaofeng Xu, Yueqiang Cao, Wei Li, Jinghong Zhou, Xinggui Zhou. Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate[J]. Chinese Journal of Chemical Engineering, 2025, 81(5): 171-181.
Dai Zhang, Xiaofeng Xu, Yueqiang Cao, 等. Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate[J]. 中国化学工程学报（英文版）, 2025,81(5):171-181. DOI：

Dai Zhang, Xiaofeng Xu, Yueqiang Cao, Wei Li, Jinghong Zhou, Xinggui Zhou. Thermodynamics insights into the gas-phase synthesis of glycolide from methyl glycolate[J]. Chinese Journal of Chemical Engineering, 2025, 81(5): 171-181. DOI：

摘要

Abstract

Gas-phase synthesis of glycolide (GL) from methyl glycolate (MG) is of great significance for producing biodegradable polyglycolic acid. Here

we report a detailed thermodynamics study for the gas-phase synthesis of GL from MG

which involves complex reaction pathways

by utilizing the Gibbs free energy minimization method. The results indicate that the decompositions of MG and GL and the polymerization of MG are thermodynamically favorable as compared with the target pathway

i.e.

the cyclization of MG. Effects of the reaction conditions including temperature

pressure and feed composition on the formation of GL and linear polymers have also been addressed

which demonstrate that the higher temperature and lower pressure can effectively inhibit the formation of linear methyl ester dimer and improve the selectivity to GL. In addition

the higher N

/MG ratio is beneficial for the formation of GL in the process promoted by catalysts. These thermodynamics results indicate that the process promoted by catalysts would benefit from the kinetics control by high-performance catalysts and the operation at high temperature

low pressure and high N

/MG ratio to enhance the yield of targeted GL. The insights demonstrated here from thermodynamics are valuable for guiding the design of catalysts and/or optimization of reaction conditions for the gas-phase synthesis of GL from MG.

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