Kinetic modeling of gamma-aminobutyric acid production by <i>Lactobacillus brevis</i> based on pH-dependent model and rolling correction

Min Wu; Juanjuan Ding; Zhaofeng Zhang; Shengping You; Wei Qi; Rongxin Su; Zhimin He

Your Location：

Home >

Browse articles >

Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction

Biotechnology and Bioengineering | Updated：2026-01-06

- Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction
- Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction
- 中国化学工程学报（英文版） 2022年50卷第10期页码：352-360
- Affiliations：
  
  1. Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University,Tianjin,China,300350
  2. Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University,Tianjin,China,300072
  3. State Key Laboratory of Chemical Engineering, Tianjin University,Tianjin,China,300350
  4. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin),Tianjin,China,300072
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2022
- Accepted：
Scan QR Code
Min Wu, Juanjuan Ding, Zhaofeng Zhang, 等. Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction[J]. 中国化学工程学报（英文版）, 2022,50(10):352-360.

based on pH-dependent model and rolling correction[J]. 中国化学工程学报, 2022, 50(10): 352-360.
Min Wu, Juanjuan Ding, Zhaofeng Zhang, 等. Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction[J]. 中国化学工程学报（英文版）, 2022,50(10):352-360. DOI：

based on pH-dependent model and rolling correction[J]. 中国化学工程学报, 2022, 50(10): 352-360. DOI：

摘要

Abstract

Gamma-aminobutyric acid (GABA) is a natural non-protein functional amino acid

which has potential for fermentation industrial production by

Lactobacillus brevis

. This work investigated the batch fermentation process and developed a kinetic model based on substrate restrictive model established by experimental data from L

) orthogonal experiments. In this study

the OD

600

value of fermentation broth was fixed to constant after reaching its maximum because the microorganism death showed no effect on the enzyme activity of glutamate decarboxylase (GAD). As pH is one of the key parameters in fermentation process

a pH-dependent kinetic model based on radial basis function was developed to enhance the practicality of the model. Furthermore

as to decrease the deviations between the simulated curves and the experimental data

the rolling correction strategy with OD

600

values that was measured in real-time was introduced into this work to modify the model. Finally

the accuracy of the rolling corrected and pH-dependent model was validated by good fitness between the simulated curves and data of the initial ba

tch fermentation (pH 5.2). As a result

this pH-dependent kinetic model revealed that the optimal pH for biomass growth is 5.6-5.7 and for GABA production is about 5

respectively. Therefore

the developed model is practical and convenient for the instruction of GABA fermentation production

and it has instructive significance for the industrial scale.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

A soft sensing method for biomanufacturing processes based on physics-informed variational learning with applications

Analysis of the competitive reaction rates of dibenzothiophene and naphthalene in the hydrodenitrogenation of 1,2,3,4-tetrahydroquinoline over Pt-based catalysts

Kinetic modeling and multi-objective optimization of an industrial hydrocracking process with an improved SPEA2-PE algorithm

SmdaNet: A hierarchical hard sample mining and domain adaptation neural network for fault diagnosis in industrial process

Process fault root cause diagnosis through state evolution mapping based on temporal unit shapelets

Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction

Kinetic modeling of gamma-aminobutyric acid production by Lactobacillus brevis based on pH-dependent model and rolling correction

DOI：

摘要

Abstract

关键词

Keywords

references