Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure

Shuangfei Zhao; Yingying Nie; Wenyan Zhang; Runze Hu; Lianzhu Sheng; Wei He; Ning Zhu; Yuguang Li; Dong Ji; Kai Guo

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Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure

Full Length Article | Updated：2026-01-06

- Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure
- Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure
- 中国化学工程学报（英文版） 2023年56卷第4期页码：255-265
- Affiliations：
  
  1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University,Nanjing,China,211816
  2. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University,Nanjing,China,211816
  3. Institute of Nanjing Advanced Biomaterials & Processing Equipment,Nanjing,China,211299
- Author bio：
- Funds：
  
  The research has been supported by the National Key Research and Development Program of China (2021YFC2101900 and 2019YFA0905000);National Natural Science Foundation of China (21908094, 21776130 and 22078150);Nanjing International Joint Research and Development Project (202002037);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.
- DOI：
  中图分类号：
- 纸质出版：2023
- Accepted：
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Shuangfei Zhao, Yingying Nie, Wenyan Zhang, 等. Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure[J]. 中国化学工程学报（英文版）, 2023,56(4):255-265.

Shuangfei Zhao, Yingying Nie, Wenyan Zhang, Runze Hu, Lianzhu Sheng, Wei He, Ning Zhu, Yuguang Li, Dong Ji, Kai Guo. Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 255-265.
Shuangfei Zhao, Yingying Nie, Wenyan Zhang, 等. Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure[J]. 中国化学工程学报（英文版）, 2023,56(4):255-265. DOI：

Shuangfei Zhao, Yingying Nie, Wenyan Zhang, Runze Hu, Lianzhu Sheng, Wei He, Ning Zhu, Yuguang Li, Dong Ji, Kai Guo. Microfluidic field strategy for enhancement and scale up of liquid–liquid homogeneous chemical processes by optimization of 3D spiral baffle structure[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 255-265. DOI：

摘要

Abstract

Due to the scale effect

the uniform distribution of reagents in continuous flow reactor becomes bad when the channel is enlarged to tens of millimeters. Microfluidic field strategy was proposed to produce high mixing efficiency in large-scale channel. A 3D spiral baffle structure (3SBS) was designed and optimized to form microfluidic field disturbed by continuous secondary flow in millimeter scale Y-shaped tube mixer (YSTM). Enhancement effect of the 3SBS in liquid–liquid homogeneous chemical processes was verified and evaluated through the combination of simulation and experiment. Compared with 1 mm YSTM

10 mm YSTM with 3SBS increased the treatment capacity by 100 times

shortened the basic complete mixing time by 0.85 times

which proves the potential of microfluidic field strategy in enhancement and scale-up of liquid–liquid homogeneous chemical process.

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