High-efficiency and safe synthesis of tonalid <i>via</i> two Friedel-Crafts reactions in continuous-flow microreactors

Yang Han; Yuanyuan Liu; Shiwei Wang; Xuehui Ge; Xiaoda Wang; Ting Qiu

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High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors

Full Length Article | Updated：2026-01-06

- High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors
- High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors
- 中国化学工程学报（英文版） 2022年52卷第12期页码：126-135
- Affiliations：
  
  Engineering Research Center of Reactive Distillation, Fujian Province Higher Education Institutes, College of Chemical Engineering, Fuzhou University, Fuzhou 350108, China Qingyuan Innovation Laboratory,Quanzhou,China,362801
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2022
- Accepted：
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Yang Han, Yuanyuan Liu, Shiwei Wang, 等. High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors[J]. 中国化学工程学报（英文版）, 2022,52(12):126-135.

two Friedel-Crafts reactions in continuous-flow microreactors[J]. 中国化学工程学报, 2022, 52(12): 126-135.
Yang Han, Yuanyuan Liu, Shiwei Wang, 等. High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors[J]. 中国化学工程学报（英文版）, 2022,52(12):126-135. DOI：

two Friedel-Crafts reactions in continuous-flow microreactors[J]. 中国化学工程学报, 2022, 52(12): 126-135. DOI：

摘要

Abstract

Tonalid

an important fragrance ingredient with widespread application

was synthesized

via

two Friedel-Crafts reactions

which were catalyzed by AlCl

. The traditional tonalid production was conducted in batch stirring tank reactors

suffering from low production capacity and the safety hazard of temperature runaway. To solve these problems

the continuous-flow technologies were developed for the high-efficiency and intrinsically safe synthesis of tonalid in microreactors. Catalyst AlCl

was neatly homogenized in proper solvents by forming complex with reactant

which was a necessary step for the continuous synthesis in microreactors. Several reaction conditions

including reactant molar ratio

catalyst concentration

temperature

and microchannel hydrodynamic diameter

were investigated for the two Friedel-Crafts reactions in microreactors. At optimized conditions

the yields of the two Friedel-Crafts reactions were 44.15% and 97.55%

respectively. In comparison with the batch reactors

the reaction times of these two reactions could both be reduced by nearly two thirds in microreactors at the similar yield.

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High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors

High-efficiency and safe synthesis of tonalid via two Friedel-Crafts reactions in continuous-flow microreactors

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摘要

Abstract

关键词

Keywords

references