Flexibility analysis for continuous ibuprofen manufacturing processes

Wenhui Yang; Haoyu Yin; Zhihong Yuan; Bingzhen Chen

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Flexibility analysis for continuous ibuprofen manufacturing processes

Full Length Article | Updated：2026-01-06

- Flexibility analysis for continuous ibuprofen manufacturing processes
- Flexibility analysis for continuous ibuprofen manufacturing processes
- 中国化学工程学报（英文版） 2022年51卷第11期页码：115-125
- Affiliations：
  
  1. State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
  2. School of Material Science and Engineering, Tsinghua University,Beijing,China,100084
  3. Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
- Author bio：
- Funds：
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  中图分类号：
- 纸质出版：2022
- Accepted：
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Wenhui Yang, Haoyu Yin, Zhihong Yuan, 等. Flexibility analysis for continuous ibuprofen manufacturing processes[J]. 中国化学工程学报（英文版）, 2022,51(11):115-125.

Wenhui Yang, Haoyu Yin, Zhihong Yuan, Bingzhen Chen. Flexibility analysis for continuous ibuprofen manufacturing processes[J]. Chinese Journal of Chemical Engineering, 2022, 51(11): 115-125.
Wenhui Yang, Haoyu Yin, Zhihong Yuan, 等. Flexibility analysis for continuous ibuprofen manufacturing processes[J]. 中国化学工程学报（英文版）, 2022,51(11):115-125. DOI：

Wenhui Yang, Haoyu Yin, Zhihong Yuan, Bingzhen Chen. Flexibility analysis for continuous ibuprofen manufacturing processes[J]. Chinese Journal of Chemical Engineering, 2022, 51(11): 115-125. DOI：

摘要

Abstract

Continuous ibuprofen (a widespread used analgesic drug) manufacturing is full of superiorities and is a fertile field both in industry and academia since it can not only effectively treat rheumatic and other chronic and painful diseases

but also shows great potential in dental diseases. As one of central elements of operability analysis

flexibility analysis is in charge of the quantitative assessment of the capability to guarantee the feasible operation in face of variations on uncertain parameters. In this paper

we focus on the flexibility index calculation for the continuous ibuprofen manufacturing process. We update existing state-of-the-art formulations

which traditionally lead to the max-max-max optimization problem

to approach the calculation of the flexibility index with a favorable manner. Advantages regarding the size of the mathematical model and the computational CPU time of the modified method are examined by four cases. In addition to identifying the flexibility index without any consideration of control variables

we also investigate the effects of different combinations of control variables on the flexibility property to reveal the benefits from taking recourse actions into account. Results from systematic investigations are expected to provide a solid basis for the further control system design and optimal operation of continuous ibuprofen manufacturing.

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