Biomanufacturing

which uses renewable resources as raw materials and uses biological processes to produce energy and chemicals

has long been regarded as a production model that replaces the unsustainable fossil economy. The construction of non-natural and efficient biosynthesis routes of chemicals is an important goal of green biomanufacturing. Traditional methods that rely on experience are difficult to support the realization of this goal. However

with the rapid development of information technology

the intelligence of biomanufacturing has brought hope to achieve this goal. Retrobiosynthesis and computational enzyme design

as two of the main technologies in intelligent biomanufacturing

have developed rapidly in recent years and have made great achievements and some representative works have demonstrated the great value that the integration of the two fields may bring. To achieve the final integration of the two fields

it is necessary to examine the information

methods and tools from a bird’s-eye view

and to find a feasible idea and solution for establishing a connection point. For this purpose

this article briefly reviewed the main ideas

methods and tools of the two fields

and put forward views on how to achieve the integration of the two fields.