Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers

Jing Zhao; Zhiguang Duan; Xiaoxuan Ma; Yannan Liu; Daidi Fan

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Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers

Biomedical Engineering | Updated：2026-01-06

- Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers
- Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers
- 中国化学工程学报（英文版） 2021年29卷第2期页码：291-300
- Affiliations：
  
  1. Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University,Xi'an,China,710069
  2. Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University,Xi'an,China,710069
  3. Biotech. &Biomed. Research Institute, Northwest University,Xi'an,China,710069
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, 等. Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers[J]. 中国化学工程学报（英文版）, 2021,29(2):291-300.

Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, Yannan Liu, Daidi Fan. Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 291-300.
Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, 等. Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers[J]. 中国化学工程学报（英文版）, 2021,29(2):291-300. DOI：

Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, Yannan Liu, Daidi Fan. Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 291-300. DOI：

摘要

Abstract

Ginsenosides are the main pharmacologically active constituents of ginseng which have been used in East Asian countries for centuries to modulate blood pressure

metabolism and immune function. Following the technological advances in isolation

purification and mass production

their mechanisms of action are gradually elucidated

providing solid basis for clinical applications. Ginseng extracts (total ginsenosides) and ginsenoside Rg3

Rd have been marketed or entered clinical trials as drugs or dietary supplements. Despite the proven safety and efficacy of some ginsenosides

their applications are hindered by inferior pharmacokinetics such as low solubility

poor membrane permeability and metabolic instability. Nanoparticle formulation of drugs and implantable drug depots are effective strategies to improve the pharmacokinetics of therapeutic agents by enhancing solubility

providing protection

facilitating intracellular transport

and enabling sustained and controlled release. This mini-review summarizes the recent advances in systemic delivery of ginsenosides using liposomes

micelles

albumin-based nanoparticles

and inorganic nanoparticles

as well as local delivery of ginsenosides by electronspun fibrous membranes and hydrogels.

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