The potential of ionic liquids in biopharmaceutical engineering

Xuan Lin; Zhiguo Su; Yanli Yang; Songping Zhang

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The potential of ionic liquids in biopharmaceutical engineering

Biomedical Engineering | Updated：2026-01-06

- The potential of ionic liquids in biopharmaceutical engineering
- The potential of ionic liquids in biopharmaceutical engineering
- 中国化学工程学报（英文版） 2021年29卷第2期页码：236-243
- Affiliations：
  
  State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences,Beijing,China,100190
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Xuan Lin, Zhiguo Su, Yanli Yang, 等. The potential of ionic liquids in biopharmaceutical engineering[J]. 中国化学工程学报（英文版）, 2021,29(2):236-243.

Xuan Lin, Zhiguo Su, Yanli Yang, Songping Zhang. The potential of ionic liquids in biopharmaceutical engineering[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 236-243.
Xuan Lin, Zhiguo Su, Yanli Yang, 等. The potential of ionic liquids in biopharmaceutical engineering[J]. 中国化学工程学报（英文版）, 2021,29(2):236-243. DOI：

Xuan Lin, Zhiguo Su, Yanli Yang, Songping Zhang. The potential of ionic liquids in biopharmaceutical engineering[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 236-243. DOI：

摘要

Abstract

Biopharmaceuticals

such as proteins

peptides

nucleic acids and vaccines

bring about great hopes for the prevention and treatment of various diseases

but the industrialization of these products still faces challenges such as structural instability

inefficient bioactivity and low bioavailability. Ionic liquids (ILs)

the marvelous solvent media with inimitable and tunable properties

may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization

protection

and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However

challenges remain on the toxicity and safety issues. Besides

the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

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