Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

Jianye Xia; Guan Wang; Meng Fan; Min Chen; Zeyu Wang; Yingping Zhuang

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Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

Biocatalysis and Bioreactor Engineering | Updated：2026-01-06

- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains
- Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains
- 中国化学工程学报（英文版） 2021年29卷第2期页码：178-184
- Affiliations：
  
  State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology,Shanghai,China,200237
- Author bio：
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- 纸质出版：2021
- Accepted：
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Jianye Xia, Guan Wang, Meng Fan, 等. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains[J]. 中国化学工程学报（英文版）, 2021,29(2):178-184.

Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, Yingping Zhuang. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 178-184.
Jianye Xia, Guan Wang, Meng Fan, 等. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains[J]. 中国化学工程学报（英文版）, 2021,29(2):178-184. DOI：

Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, Yingping Zhuang. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 178-184. DOI：

摘要

Abstract

The production capability of a fermentation process is predominately determined by individual strains

which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.

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