The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates (D-glucose/D-sucrose) are investigated by using volumetric

viscometric and acoustic properties. The measurements of the densities

ρ

ultrasonic speeds

u

and viscosities

η

. of semicarbazide hydrochloride in 5% and 10% D-glucose/D-sucrose+water (w/w) solutions were carried out at temperatures (293.15-318.15) K and at pressure

p

=101 kPa. The apparent molar volumes

V

ϕ

limiting apparent molar volumes

V

ϕ

°

apparent molar compressibilities

K

s

ϕ

limiting apparent molar compressibilities

K

s

ϕ

°

partial molar expansibilities

E

ϕ

°

transfer volumes

V

ϕ

tr

° and transfer compressibilities

K

s

ϕ

tr

° have been calculated from the experimental data. The viscosity data were examined by using the Jones-Dole equation and the viscosity

A

and

B

coefficients were evaluated. The results are discussed in terms o

f solute-solute and solute-solvent interactions in these solutions. The structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of

B

-coefficient

d

B

/d

T

.