Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge

Mengjiao Xu; Zhuotao Tan; Chenjie Zhu; Wei Zhuang; Hanjie Ying; Pingkai Ouyang

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Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge

Biocatalysis and Bioreactor Engineering | Updated：2026-01-06

- Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge
- Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge
- 中国化学工程学报（英文版） 2021年29卷第2期页码：146-167
- Affiliations：
  
  College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University,Nanjing,China,211816
- Author bio：
- Funds：
  
  The authors thank the financial support by National Natural Science Foundation of China (21776132, 21878142);Jiangsu Province Natural Science Foundation for Distinguished Young Scholars (BK20190035);National Key Research and Development Program of China (2019YFD1101202);Jiangsu Province Natural Science Foundation for Youths (BK20200685);China Postdoctoral Science Foundation (2019M660113).
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Mengjiao Xu, Zhuotao Tan, Chenjie Zhu, 等. Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge[J]. 中国化学工程学报（英文版）, 2021,29(2):146-167.

Mengjiao Xu, Zhuotao Tan, Chenjie Zhu, Wei Zhuang, Hanjie Ying, Pingkai Ouyang. Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 146-167.
Mengjiao Xu, Zhuotao Tan, Chenjie Zhu, 等. Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge[J]. 中国化学工程学报（英文版）, 2021,29(2):146-167. DOI：

Mengjiao Xu, Zhuotao Tan, Chenjie Zhu, Wei Zhuang, Hanjie Ying, Pingkai Ouyang. Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 146-167. DOI：

摘要

Abstract

Chemoenzymatic catalysis can give full play to the advantages of versatile reactivity of chemocatalysis and excellent chemo-

regio-

and stereoselectivities of biocatalysis. These chemoenzymatic methods can not only save resource

cost

and operating time but also reduce the number of reaction steps

and avoid separating unstable intermediates

leading to the generation of more products under greener circumstances and thereby playing an indispensable role in the fields of medicine

materials and fine chemicals. Although incompatible challenges between chemocatalyst and biocatalyst remain

strategies such as biphasic system

artificial metalloenzymes

immobilization or supramolecular host

and protein engineering have been designed to overcome these issues. In this review

chemoenzymatic catalysis according to different chemocatalysis types was classifiably described

and in particular

the classic dynamic kinetic resolutions (DKR) and cofactor regeneration were summarized. Finally

the bottlenecks and development of chemoenzymatic catalysis were summarized

and future development was prospected.

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