Microbial production of L-malate from renewable non-food feedstocks

Youming Jiang; Xiaohan Ye; Tianwen Zheng; Weiliang Dong; Fengxue Xin; Jiangfeng Ma; Min Jiang

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Microbial production of L-malate from renewable non-food feedstocks

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Microbial production of L-malate from renewable non-food feedstocks
- Microbial production of L-malate from renewable non-food feedstocks
- 中国化学工程学报（英文版） 2021年29卷第2期页码：105-111
- Affiliations：
  
  State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University,Nanjing,China,211800
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Youming Jiang, Xiaohan Ye, Tianwen Zheng, 等. Microbial production of L-malate from renewable non-food feedstocks[J]. 中国化学工程学报（英文版）, 2021,29(2):105-111.

Youming Jiang, Xiaohan Ye, Tianwen Zheng, Weiliang Dong, Fengxue Xin, Jiangfeng Ma, Min Jiang. Microbial production of L-malate from renewable non-food feedstocks[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 105-111.
Youming Jiang, Xiaohan Ye, Tianwen Zheng, 等. Microbial production of L-malate from renewable non-food feedstocks[J]. 中国化学工程学报（英文版）, 2021,29(2):105-111. DOI：

Youming Jiang, Xiaohan Ye, Tianwen Zheng, Weiliang Dong, Fengxue Xin, Jiangfeng Ma, Min Jiang. Microbial production of L-malate from renewable non-food feedstocks[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 105-111. DOI：

摘要

Abstract

L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms

and it has been widely applied in polymer

beverage and food

textile

agricultural and pharmaceutical industries. Driven by the pursuit of a sustainable economy

microbial production of L-malate has received much attention in last decades. In this review

we focus on the utilization of wastes and/or byproducts as feedstocks for the microbial production of L-malate. Firstly

we present the recent developments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate

and also provide a comprehensive discussions on developing high-efficient producers. Then

the recent achievements in microbial production of L-malate from various carbon sources were concluded and discussed. Furthermore

some abundant non-food feedstocks which have been used for microbial production of other chemicals were reviewed

as they may be potential candidate feedstock for L-malate production in future. Finally

we outlined the major challenges and proposed further improvements for the production of L-malate.

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