<i>Aureobasidium subglaciale</i> F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature

Liqun Shen; Ran Cang; Guang Yang; Anqi Zeng; He Huang; Zhigang Zhang

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Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature

Catalysis, Kinetics and Reaction Engineering | Updated：2026-01-06

- Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature
- Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature
- 中国化学工程学报（英文版） 2020年28卷第12期页码：3044-3051
- Affiliations：
  
  1. School of Pharmaceutical Sciences, Nanjing Tech University,Nanjing,China,211816
  2. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University,Nanjing,China,211816
- Author bio：
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- 纸质出版：2020
- Accepted：
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Liqun Shen, Ran Cang, Guang Yang, 等. Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature[J]. 中国化学工程学报（英文版）, 2020,28(12):3044-3051.

F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature[J]. 中国化学工程学报, 2020, 28(12): 3044-3051.
Liqun Shen, Ran Cang, Guang Yang, 等. Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature[J]. 中国化学工程学报（英文版）, 2020,28(12):3044-3051. DOI：

F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature[J]. 中国化学工程学报, 2020, 28(12): 3044-3051. DOI：

摘要

Abstract

The microbial production of either ester/lactones or enantio-enriched alcohols through Baeyer-Villiger oxidation or stereoselective reduction of ketones

respectively

is possible by using whole cells of

A. subglaciale

F134 as a bifunctional biocatalyst. The chemoselective pattern of acetophenone biotransformation catalyzed by these cells can be regulated through reaction temperature

directing the reaction either towards oxidation or reduction products. The Baeyer-Villiger oxidation activity of

A. subglaciale

F134 whole cells is particularly dependent on reaction temperature. Acetophenone was transformed efficiently to phenol

via

the primary Baeyer-Villiger product phenyl acetate at 20℃ after 48 h with 100% conversion. In contrast

at 35℃

enantio-enriched (S)-1-phenylethanol was obtained as the sole product with 64% conversion and 89% ee. In addition

A. subglaciale

F134 cells also catalyze the selective reduction of various structurally different aldehydes and ketones to alcohols with 40% to 100% yield

indicating broad substrate spectrum and good enantioselectivity in re

levant cases. Our study provides a bifunctional biocatalyst system that can be used in Baeyer-Villiger oxidation as well as in asymmetric carbonyl reduction

setting the stage for future work concerning the identification and isolation of the respective enzymes.

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Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature

Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature

DOI：

摘要

Abstract

关键词

Keywords

references