The development of <i>Fructus corni</i> quality standard considering the effects of processing

Xingchu Gong; Junlin Guo; Jingjing Pan; Zhenfeng Wu

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The development of Fructus corni quality standard considering the effects of processing

Separation Science and Engineering | Updated：2026-01-06

- The development of Fructus corni quality standard considering the effects of processing
- The development of Fructus corni quality standard considering the effects of processing
- 中国化学工程学报（英文版） 2021年29卷第1期页码：77-84
- Affiliations：
  
  1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine,Nanchang,China,330004
  2. Tianjin University of Traditional Chinese Medicine, Graduate College,Tianjin,China,300193
  3. Pharmaceutical Informatics Institute, College of Pharmaceutical Science, Zhejiang University,Hangzhou,China,310058
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Xingchu Gong, Junlin Guo, Jingjing Pan, 等. The development of Fructus corni quality standard considering the effects of processing[J]. 中国化学工程学报（英文版）, 2021,29(1):77-84.

quality standard considering the effects of processing[J]. 中国化学工程学报, 2021, 29(1): 77-84.
Xingchu Gong, Junlin Guo, Jingjing Pan, 等. The development of Fructus corni quality standard considering the effects of processing[J]. 中国化学工程学报（英文版）, 2021,29(1):77-84. DOI：

quality standard considering the effects of processing[J]. 中国化学工程学报, 2021, 29(1): 77-84. DOI：

摘要

Abstract

The quality standards for

Fructus Corni

have been established based on the effects of the manufacturing processes. Three critical process parameters (CPPs) of extraction

filtration

and concentration to prepare

Fructus Corni

concentrate were identified by Plackett-Burman design with a single batch of

Fructus Corni

which were heating medium temperature

extraction time

and water addition. Morroniside yield

loganin yield

and dry matter yield were process critical quality attributes (CQAs). CPPs arranged with a Box-Behnken design were applied to treat different batches of

Fructus Corni

. After constructing a model that included CPPs

material properties

and process CQAs

loganin content was found to be the critical material attribute (CMA). The design space was calculated with a probability method. According to the limits of process CQAs

the minimum content of loganin in

Fructus Corni

was calculated with an error propagation method

which was 6.92 mg·g

-1

. When the content of loganin in

Fructus Corni

reaches up to 6.92 mg·g

-1

the material is considered high-quality and is most suitable for the process. High-quality material can

be used for production of

Fructus Corni

concentrate. This method can also be used to set material quality standards for other Chinese medicines.

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The development of Fructus corni quality standard considering the effects of processing

The development of Fructus corni quality standard considering the effects of processing

DOI：

摘要

Abstract

关键词

Keywords

references