Recombinant protein production in the filamentous fungus <i>Trichoderma</i>

Huiling Wei; Mengyue Wu; Aili Fan; Haijia Su

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Recombinant protein production in the filamentous fungus Trichoderma

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Recombinant protein production in the filamentous fungus Trichoderma
- Recombinant protein production in the filamentous fungus Trichoderma
- 中国化学工程学报（英文版） 2021年29卷第2期页码：74-81
- Affiliations：
  
  Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District,Beijing,China,100029
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Huiling Wei, Mengyue Wu, Aili Fan, 等. Recombinant protein production in the filamentous fungus Trichoderma[J]. 中国化学工程学报（英文版）, 2021,29(2):74-81.

[J]. 中国化学工程学报, 2021, 29(2): 74-81.
Huiling Wei, Mengyue Wu, Aili Fan, 等. Recombinant protein production in the filamentous fungus Trichoderma[J]. 中国化学工程学报（英文版）, 2021,29(2):74-81. DOI：

[J]. 中国化学工程学报, 2021, 29(2): 74-81. DOI：

摘要

Abstract

Trichoderma

is an ascomycete fungal genus widely distributed in the soils. Several species were selected

engineered and utilized for protein production for decades. The high extracellular secretion capability and eukaryotic post-translational modification machinery make

Trichoderma

spp. particularly interesting hosts. In this review

we summarized the recombinant proteins produced in

Trichoderma

since 2014

concerning their origins

hosts

promoters

terminators

signal peptides

yields and commonly used media. Meanwhile

strategies and merging trends in protein production and strain engineering are classified and summarized regarding codon optimization

promoter utilization

transcription factor regulation

post-translational modification and proteolytic degradation inhibition. With state-of-art biotechnologies and more available expression platforms

Trichoderma

spp. could be more successful hosts to produce recombinant proteins as desired

i.e

. better enzyme formula for efficient cellulose degradation or functional protein with high purity and yield.

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Recombinant protein production in the filamentous fungus Trichoderma

Recombinant protein production in the filamentous fungus Trichoderma

DOI：

摘要

Abstract

关键词

Keywords

references