Engineered microorganisms and enzymes for efficiently synthesizing plant natural products

Wenqiang Li; Wentao Sun; Chun Li

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Engineered microorganisms and enzymes for efficiently synthesizing plant natural products

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Engineered microorganisms and enzymes for efficiently synthesizing plant natural products
- Engineered microorganisms and enzymes for efficiently synthesizing plant natural products
- 中国化学工程学报（英文版） 2021年29卷第2期页码：62-73
- Affiliations：
  
  Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
- Author bio：
- Funds：
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  中图分类号：
- 纸质出版：2021
- Accepted：
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Wenqiang Li, Wentao Sun, Chun Li. Engineered microorganisms and enzymes for efficiently synthesizing plant natural products[J]. 中国化学工程学报（英文版）, 2021,29(2):62-73.

Wenqiang Li, Wentao Sun, Chun Li. Engineered microorganisms and enzymes for efficiently synthesizing plant natural products[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 62-73.
Wenqiang Li, Wentao Sun, Chun Li. Engineered microorganisms and enzymes for efficiently synthesizing plant natural products[J]. 中国化学工程学报（英文版）, 2021,29(2):62-73. DOI：

Wenqiang Li, Wentao Sun, Chun Li. Engineered microorganisms and enzymes for efficiently synthesizing plant natural products[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 62-73. DOI：

摘要

Abstract

Plant natural products are a kind of active substance widely used in pharmaceuticals and foods. However

the current production mode based on plant culture and extraction suffer complex processes and severe concerns for environmental and ecological. With the increasing awareness of environmental sustainability

engineered microbial cell factories have been an alternative approach to produce natural products. Many engineering strategies have been utilized in microbial biosynthesis of complex phytochemicals such as dynamic control and substructure engineering. Meanwhile

Enzyme engineering including directed evolution and rational design has been implemented to improve enzyme catalysis efficiency and stability as well as change promiscuity to expand product spectra. In this review

we discussed recent advances in microbial biosynthesis of complex phytochemicals from the following aspects

including pathway construction

strain engineering to boost the production.

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