Recent advances in microbial production of phenolic compounds

Xinxiao Sun; Xianglai Li; Xiaolin Shen; Jia Wang; Qipeng Yuan

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Recent advances in microbial production of phenolic compounds

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Recent advances in microbial production of phenolic compounds
- Recent advances in microbial production of phenolic compounds
- 中国化学工程学报（英文版） 2021年29卷第2期页码：54-61
- Affiliations：
  
  State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology,Beijing,China,100029
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2021
- Accepted：
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Xinxiao Sun, Xianglai Li, Xiaolin Shen, 等. Recent advances in microbial production of phenolic compounds[J]. 中国化学工程学报（英文版）, 2021,29(2):54-61.

Xinxiao Sun, Xianglai Li, Xiaolin Shen, Jia Wang, Qipeng Yuan. Recent advances in microbial production of phenolic compounds[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 54-61.
Xinxiao Sun, Xianglai Li, Xiaolin Shen, 等. Recent advances in microbial production of phenolic compounds[J]. 中国化学工程学报（英文版）, 2021,29(2):54-61. DOI：

Xinxiao Sun, Xianglai Li, Xiaolin Shen, Jia Wang, Qipeng Yuan. Recent advances in microbial production of phenolic compounds[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 54-61. DOI：

摘要

Abstract

Phenolic compounds (PCs) are a group of compounds with various applications in nutraceutical

pharmaceutical and cosmetic industries. Their supply by plant extraction and chemical synthesis is often limited by low yield and high cost. Microbial production represents as a promising alternative for efficient and sustainable production of PCs. In this review

we summarize recent advances in this field

which include enzyme mining and engineering to construct artificial pathways

balance of enzyme expression to improve pathway efficiency

coculture engineering to alleviate metabolic burden and side-reactions

and the use of genetic circuits for dynamic regulation and high throughput screening. Finally

current challenges and future perspectives for efficient production of PCs are also discussed.

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