Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K

Pengbao Lian; Qiang Liu; Lizhen Chen; Cai Cao; Jiaxiang Zhao; Jianlong Wang

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Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K

Chemical Engineering Thermodynamics | Updated：2026-01-06

- Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K
- Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K
- 中国化学工程学报（英文版） 2020年28卷第10期页码：2634-2639
- Affiliations：
  
  1. School of Chemical Engineering and Technology, North University of China,Taiyuan,China,030051
  2. Hubei Dongfang Chemical Industry Co., Ltd, Xiangyang,China,441403
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2020
- Accepted：
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Pengbao Lian, Qiang Liu, Lizhen Chen, 等. Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K[J]. 中国化学工程学报（英文版）, 2020,28(10):2634-2639.

Pengbao Lian, Qiang Liu, Lizhen Chen, Cai Cao, Jiaxiang Zhao, Jianlong Wang. Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2634-2639.
Pengbao Lian, Qiang Liu, Lizhen Chen, 等. Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K[J]. 中国化学工程学报（英文版）, 2020,28(10):2634-2639. DOI：

Pengbao Lian, Qiang Liu, Lizhen Chen, Cai Cao, Jiaxiang Zhao, Jianlong Wang. Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2634-2639. DOI：

摘要

Abstract

In this paper

the solubility of 4-nitroimidazole in twelve pure solvents (toluene

benzene

4-dioxane

acetonitrile

ethyl acetate

acetone

GBL

ethanol

methanol

-butanol

DMF and NMP) were determined by using the laser monitoring system from 278.15 K to 323.15 K under 101.1 kPa

which are 0.00018-0.00070

0.00021-0.00073

0.00034-0.00092

0.00038-0.00142

0.00047-0.00120

0.00126-0.00303

0.00225-0.00517

0.00310-0.00724

0.00467-0.00982

0.00453-0.01940

0.01947-0.04652

and 0.04670-0.07452

respectively. At constant temperature

the mole fraction solubility of 4-nitroimidazole were increased as the following order: toluene benzene 1

4-dioxane (ethyl acetate or acetonitrile) acetone GBL ethanol (methanol or nbutanol) DMF NMP

and the solubility of 4-nitroimidazole in (ethyl acetate

acetonitrile) and (methanol

-butanol) had an intersection point at 297.55 K and 281.85 K

respectively. The solubility of 4-nitroimidazole could be increased with increasing temperature in twelve pure solvents. The ideal model

modified Apelblat equation

polynomial empirical equation

and

λh

equation were used to correlate the experimental values. The experimental s

olubility values were employed to calculate the standard dissolution enthalpy

standard dissolution entropy and Gibbs energy. The dissolution of 4-nitroimidazole could be an endothermic process in twelve pure solvents. The determination and fitting solubility of 4-nitroimidazole have important guiding significance for the purification and crystallization of its preparation process.

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