Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

Qiao Chen; Fengxia Zou; Pengpeng Yang; Jingwei Zhou; Jinglan Wu; Wei Zhuang; Hanjie Ying

Your Location：

Home >

Browse articles >

Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

Chemical Engineering Thermodynamics | Updated：2026-01-06

- Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives
- Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives
- 中国化学工程学报（英文版） 2018年26卷第10期页码：2112-2120
- Affiliations：
  
  1. 2 College of Biotechnology and Pharmaceutical Engineering, National Engineering Research Center for Biotechnology, Nanjing Tech University,Nanjing,China,210009
  2. 3 College of Chemistry and Chemical Engineering, Nantong University,Nantong,China,226019
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2018
- Accepted：
Scan QR Code
Qiao Chen, Fengxia Zou, Pengpeng Yang, 等. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. 中国化学工程学报（英文版）, 2018,26(10):2112-2120.

Qiao Chen, Fengxia Zou, Pengpeng Yang, Jingwei Zhou, Jinglan Wu, Wei Zhuang, Hanjie Ying. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. Chin.J.Chem.Eng., 2018, 26(10): 2112-2120.
Qiao Chen, Fengxia Zou, Pengpeng Yang, 等. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. 中国化学工程学报（英文版）, 2018,26(10):2112-2120. DOI：

Qiao Chen, Fengxia Zou, Pengpeng Yang, Jingwei Zhou, Jinglan Wu, Wei Zhuang, Hanjie Ying. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. Chin.J.Chem.Eng., 2018, 26(10): 2112-2120. DOI：

摘要

Abstract

Microstructure and phase transformation of disodium guanosine 5'-monophosphate (5'-GMPNa

) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work

the thermodynamic properties of polymorphous 5'-GMPNa

especially the solubility were studied

the solubility results show that 5'-GMPNa

is more soluble in ethanol-water (E-W) than in isopropanol-water (I-W). The amorphous form of 5'-GMPNa

is more soluble than the crystalline form at the same mole fraction and temperature. Meanwhile

the crystalline forms and morphologies of the residual solids were characterized by PXRD and SEM. The results indicate that solid forms of 5'-GMPNa

transformed spontaneously from amorphous to crystalline when the ethanol proportion is ≥ 20%. In addition

increasing the pH facilitates the dissolution of 5'-GMPNa

and helps to maintain the crystalline form. The associated Gibbs free energy values were calculated to verify the trend of transformation from amorphous to crystalline 5'-GMPNa

. These results should help to guide the industrial crystallization process and

to obtain the crystalline form of 5'-GMPNa

关键词

Keywords

references

浏览量

163

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Evaporation crystallization for the extraction of potassium bromide from bitters by phase equilibrium

Separation of chlorineebromine-based solid solution in bittern tail solution by phase equilibrium

Solid-liquid phase equilibrium for the system ammonium polyphosphate-urea ammonium nitrate-potassium chloride-water at 273.2 K

A new approach for correlating of H2S solubility in [emim][Lac], [bmim][ac] and [emim][pro] ionic liquids using two-parts combined models

Solubility of red palm oil in supercritical carbon dioxide: Measurement and modelling