Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

Anca-Irina Galaction; Dan Cascaval; Ramona-MihaelaMatran; Alexandra Tucaliuc

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Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

第25届中国过程控制会议专栏 | Updated：2026-01-06

- Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects
- Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects
- 中国化学工程学报（英文版） 2016年24卷第4期页码：513-520
- Affiliations：
  
  2 "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Dept. of Biochemical Engineering, D. Mangeron 73,Iasi,Romania,700050
- Author bio：
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- 纸质出版：2016
- Accepted：
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Anca-Irina Galaction, Dan Cascaval, Ramona-MihaelaMatran, 等. Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects[J]. 中国化学工程学报（英文版）, 2016,24(4):513-520.

Anca-Irina Galaction, Dan Cascaval, Ramona-MihaelaMatran, Alexandra Tucaliuc. Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects[J]. Chin.J.Chem.Eng., 2016, 24(4): 513-520.
Anca-Irina Galaction, Dan Cascaval, Ramona-MihaelaMatran, 等. Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects[J]. 中国化学工程学报（英文版）, 2016,24(4):513-520. DOI：

Anca-Irina Galaction, Dan Cascaval, Ramona-MihaelaMatran, Alexandra Tucaliuc. Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects[J]. Chin.J.Chem.Eng., 2016, 24(4): 513-520. DOI：

摘要

Abstract

The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor withmobile bed is more efficient for biocatalyst particles with a diameter over 3mm

while the basket bioreactor ismore efficient for smaller biocatalyst particles and basket bed thickness below 5mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.

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