Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies

王亚军; 于蕾; 郑裕国; 王远山; 沈寅初

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Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies

分离科学与工程 | Updated：2026-01-06

- Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies
- Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies
- 中国化学工程学报（英文版） 2013年21卷第10期页码：1106-11131004-954160583-2
- Affiliations：
  
  2 Engineering Research Center of Bioconversion and Biopurification, Ministry of Education, Zhejiang University of Technology,Hangzhou,China,310014
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2013
- Accepted：
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王亚军, 于蕾, 郑裕国, 等. Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies[J]. 中国化学工程学报（英文版）, 2013,21(10):1106-11131004-954160583-2.

WANG Yajun, YU Lei, ZHENG Yuguo, WANG Yuanshan, SHEN Yinchu. Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies[J]. Chin.J.Chem.Eng., 2013, 21(10): 1106-1113.
王亚军, 于蕾, 郑裕国, 等. Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies[J]. 中国化学工程学报（英文版）, 2013,21(10):1106-11131004-954160583-2. DOI：

WANG Yajun, YU Lei, ZHENG Yuguo, WANG Yuanshan, SHEN Yinchu. Acarbose Isolation with Gel Type Strong Acid Cation Exchange Resin：Equilibrium, Kinetic and Thermodynamic Studies[J]. Chin.J.Chem.Eng., 2013, 21(10): 1106-1113. DOI：

摘要

Abstract

Acarbose

a potent α-glucosidase inhibitor

is widely used as an oral anti-diabetic drug for the treatment of the type 2

non-insulin-dependent diabetes. In this work

a gel type strong acid cation exchange resin 001×4 was applied to isolate acarbose from fermentation broth. It was demonstrated that cation exchanger 001×4 displayed a large adsorption capacity and quick exchange rate for acarbose. The static adsorption equilibrium data were well fitted to the Langmuir equation. Column adsorption experiments demonstrated that high dynamic adsorption capacity was reached at bed height of 104.4 mm

feed flow rate of 1.0 ml·min

-1

and acarbose concentration of 4.0 mg·ml

-1

. Under the optimized conditions

the column chromatography packed with cation exchanger 001×4 recovered 74.3% (by mass) of acarbose from Actinoplanes utahensis ZJB-08196 fermentation broth with purity of 80.1% (by mass)

demonstrating great potential in the practical applications in acarbose separation.

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