Reaction Characteristics of Asymmetric Synthesis of (2<i>S</i>,5<i>S</i>)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6

肖美添; 叶静; 张亚武; 黄雅燕

Your Location：

Home >

Browse articles >

Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6

Updated：2026-01-06

- Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6
- Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6
- 中国化学工程学报（英文版） 2009年17卷第3期页码：493-499
- Affiliations：
  
  1. Institute of Pharmaceutical Engineering, Huaqiao University,Xiamen,China,361021
  2. Department of Chemical and Pharmaceutical Engineering, Huaqiao University,Xiamen,China,361021
- Author bio：
- Funds：
  
  Supported by the Key Project of Science and Technology of Fujian Province (2008N0120);the Key Discipline of Biochemical Engineering of Fujian Province (Huaqiao University)
- DOI：
  中图分类号：
- 纸质出版：2009
- Accepted：
Scan QR Code
肖美添, 叶静, 张亚武, 等. Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6[J]. 中国化学工程学报（英文版）, 2009,17(3):493-499.

,5
肖美添, 叶静, 张亚武, 等. Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6[J]. 中国化学工程学报（英文版）, 2009,17(3):493-499. DOI：

,5 DOI：

摘要

Abstract

Baker’s yeast number 6 was selected by screening. It showed good catalytic activity and enantioselectivity for asymmetric reduction of 2

5-hexanedione to produce (2

)-2

5-hexanediol. Gas chromatography-mass spectrometry (GC-MS) revealed that the intermediate was (

)-5-hydroxyhexane-2-one. Reduction of 2

5-hexanedione proceeded in a two-step reaction. The hydroxyketone was initially formed

and this intermediate was further reduced to the diol. Factors influencing the product yield and the enantiomeric excess of the reduction of 2

5-hexandione catalyzed by baker’s yeast number 6 were investigated. Higher concentration (≤100 mmol·L

-1

) of 2

5-hexandione did not influence 5-hydroxyhexane-2-one production

but 2

5-hexanediol production was inhibited by excess accumulation (30 mmol·L

-1

) of intermediate. The optimal conditions were glucose as the co-substrate at an initial glucose concentration of 20 g·L

-1

34℃

pH 7.0 and cell concentration 60 g·L

-1

(cell dry mass). Under the optimal condition and an initial substrate concentration of 30 mmol·L

-1

the yield of 2

5-hexandiol was 78.7% and the enantiomeric excess of (2

)-2

5-hexandiol was 94.4% for 24-h reduction.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Asymmetric Bioreduction of 3,5-Bis(trifluoromethyl) Acetophenone to Its Corresponding Alcohol by Candida tropicalis

Asymmetric bioreduction of γ- and δ-keto acids by native carbonyl reductases from Saccharomyces cerevisiae

Using multiple site-directed modification of epoxide hydrolase to significantly improve its enantioselectivity in hydrolysis of rac-glycidyl phenyl ether

Highly efficient synthesis of (R)-1,3-butanediol via anti-Prelog reduction of 4-hydroxy-2-butanone with absolute stereoselectivity by a newly isolated Pichia kudriavzevii

Production of Chiral Aromatic Alcohol by Asymmetric Reduction with Vegetable Catalyst

Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6

Reaction Characteristics of Asymmetric Synthesis of (2S,5S)-2,5-Hexanediol Catalyzed with Baker’s Yeast Number 6

DOI：

摘要

Abstract

关键词

Keywords

references