Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K

Md Khalid Anwer; Faiyaz Shakeel

doi:10.1016/j.cjche.2014.03.006

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Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K

化工热力学 | Updated：2026-01-06

- Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K
- Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K
- 中国化学工程学报（英文版） 2015年23卷第5期页码：812-815
- Affiliations：
  
  1. 2 Center of Excellence in Biotechnology Research, King Saud University, Riyadh 11451, Saudi Arabia
  2. 3 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2014.03.006
  中图分类号：
- 纸质出版：2015
- Accepted：
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Md Khalid Anwer, Faiyaz Shakeel. Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K[J]. 中国化学工程学报（英文版）, 2015,23(5):812-815.

Md Khalid Anwer, Faiyaz Shakeel. Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K[J]. Chin.J.Chem.Eng., 2015, 23(5): 812-815.
Md Khalid Anwer, Faiyaz Shakeel. Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K[J]. 中国化学工程学报（英文版）, 2015,23(5):812-815. DOI： 10.1016/j.cjche.2014.03.006.

Md Khalid Anwer, Faiyaz Shakeel. Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K[J]. Chin.J.Chem.Eng., 2015, 23(5): 812-815. DOI： 10.1016/j.cjche.2014.03.006.

摘要

Abstract

The aimof present study was tomeasure and correlate the solubility of poorly water-soluble flavonoid diosmin in water

ethanol

isopropyl alcohol (IPA)

polyethylene glycol-400 (PEG-400) and β-cyclodextrin (β-CD) aqueous solution (0.02 mol·L

-1

). The solubility of diosmin was measured using the shake flask method from (298.15 to 333.15) K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in β-CD aqueous solution and PEG-400 as compared to water

ethanol and IPA. Based on solubility data of present study

diosmin was considered as practically insoluble in water

insoluble in ethanol IPA and soluble in PEG-400 and β-CD aqueous solution.

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