Membrane-assisted antisolvent crystallization (MAAC) is a separation process that allows for precise regulation of the crystallization process in pharmaceutical

fine chemical engineering

energy chemistry

etc. After decades of development

the current MAAC engineering lacks highly robust specialized instruments

which limits the further industrial application of the MAAC process. Herein

to guide the design and optimization of the advanced MAAC instrument (DUT-iMC)

we developed a parameter evaluation strategy based on cold model experiments. This approach utilizes the average particle size variation rate and the counts variation rate to characterize crystal size changes. The layout of the internal membrane module in DUT-iMC and the arrangement of the conveying pipeline were optimized. This improvement enhanced particle conveying characteristics

promoting more efficient transport and circulation within the module. The advanced MAAC instrument substantially automates the production process

and the internal probes accurately monitor and record process variables

allowing for precise regulation of crystal size and morphology. The optimal operating range was expanded by 150% compared to the laboratory instrument. The range of shell side flow rate options increased by 50%

and the production time can be shortened by up to 30%. This paper provides ideas and guidance for the industrialization of MAAC processes and the development of related instruments.