Deciphering and engineering high-light tolerant cyanobacteria for efficient photosynthetic cell factories

Yaru Xie; Lei Chen; Tao Sun; Weiwen Zhang

doi:10.1016/j.cjche.2020.11.002

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Deciphering and engineering high-light tolerant cyanobacteria for efficient photosynthetic cell factories

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Deciphering and engineering high-light tolerant cyanobacteria for efficient photosynthetic cell factories
- Chinese Journal of Chemical Engineering Vol. 29, Issue 2, Pages: 82-91(2021)
- Affiliations：
  
  1. Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University,Tianjin,China,300072
  2. Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education of China,Tianjin,China,300072
  3. Collaborative Innovation Center of Chemical Science and Engineering,Tianjin,China,300072
  4. Center for Biosafety Research and Strategy, Tianjin University,Tianjin,China,300072
  5. Law School, Tianjin University,Tianjin,China,300072
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.11.002
  CLC：
- Published：2021
- Accepted：
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Yaru Xie, Lei Chen, Tao Sun, Weiwen Zhang. Deciphering and engineering high-light tolerant cyanobacteria for efficient photosynthetic cell factories[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 82-91.
DOI：

Yaru Xie, Lei Chen, Tao Sun, Weiwen Zhang. Deciphering and engineering high-light tolerant cyanobacteria for efficient photosynthetic cell factories[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 82-91. DOI： 10.1016/j.cjche.2020.11.002.

摘要

Abstract

Development and utilization of “liquid sunshine” could be one of key solutions to deal with the issues of fossil fuel depletion and increasing carbon dioxide. Cyanobacteria are the only prokaryotes capable of performing oxygenic photosynthesis

and their activity accounts for ~25% of the total carbon fixation on earth. More importantly

besides their traditional roles as primary producers

cyanobacteria could be modified as “photosynthetic cell factories” to produce renewable fuels and chemicals directly from CO

driven by solar energy

with the aid of cutting-edging synthetic biology technology. Towards their large-scale biotechnological application in the future

many challenges still need to be properly addressed

among which is cyanobacterial cell factories inevitably suffer from high light (HL) stress during large-scale outdoor cultivation

resulting in photodamage and even cell death

limiting their productivity. In this review

we critically summarized recent progress on deciphering molecular mechanisms to HL- and developing HL-tolerant chassis in cyanobacteria

aiming at facilitating construction of HLresistant chassis and promote the

future application of the large-scale outdoor cultivation of cyanobacterial cell factories. Finally

the future directions on cyanobacterial chassis engineering were discussed.

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