Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system

Pei Xie; Kai Wang; Jian Deng; Guangsheng Luo

doi:10.1016/j.cjche.2020.06.001

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Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system

Catalysis, Kinetics and Reaction Engineering | Updated：2026-01-06

- Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system
- Chinese Journal of Chemical Engineering Vol. 28, Issue 8, Pages: 2092-2098(2020)
- Affiliations：
  
  The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.06.001
  CLC：
- Published：2020
- Accepted：
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Pei Xie, Kai Wang, Jian Deng, Guangsheng Luo. Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system[J]. Chinese Journal of Chemical Engineering, 2020, 28(8): 2092-2098.
DOI：

Pei Xie, Kai Wang, Jian Deng, Guangsheng Luo. Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system[J]. Chinese Journal of Chemical Engineering, 2020, 28(8): 2092-2098. DOI： 10.1016/j.cjche.2020.06.001.

摘要

Abstract

4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye (2-anilino-3-methyl-6- dibutylaminofluorane

ODB-2)

which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process

a continuous homogeneous bromination technology in a modular microreaction system has been developed

and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br

solution in CHCl

. In optimal conditions

the content of bis-brominated byproducts can be controlled less than 0.5%

which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.

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