Design and regulation of the surface and interfacial behavior of protein molecules

Qianqian Hou; Nanxing Li; Yuanyuan Chao; Shihao Li; Lin Zhang

doi:10.1016/j.cjche.2020.05.035

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Design and regulation of the surface and interfacial behavior of protein molecules

Special Topic: Biocatalysis | Updated：2026-01-06

- Design and regulation of the surface and interfacial behavior of protein molecules
- Chinese Journal of Chemical Engineering Vol. 28, Issue 11, Pages: 2837-2847(2020)
- Affiliations：
  
  Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University,Tianjin,China,300350
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.05.035
  CLC：
- Published：2020
- Accepted：
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Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang. Design and regulation of the surface and interfacial behavior of protein molecules[J]. Chinese Journal of Chemical Engineering, 2020, 28(11): 2837-2847.
DOI：

Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang. Design and regulation of the surface and interfacial behavior of protein molecules[J]. Chinese Journal of Chemical Engineering, 2020, 28(11): 2837-2847. DOI： 10.1016/j.cjche.2020.05.035.

摘要

Abstract

Surface and interfacial behavior of protein molecules are crucial for the protein function involved in many biochemical processes and biomedical products such as enzyme design

bio-separation

drug design and delivery. This article is devoted to an overview of design and regulation of the surface and interfacial behavior of protein molecules. The improvement of enzyme surface such as the directed evolution and the rational design of enzymes is introduced at first

followed by the rational design of protein interface for the protein assembly. Thereafter

the design of micro-environment and ligands are described as two examples for the design guided by protein surface. Then the design of protein surface and interface with the help of artificial intelligence will be discussed.

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