Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism

Muhammad Imran Kanjal; Majid Muneer; Amal Abdelhaleem; Wei Chu

doi:10.1016/j.cjche.2020.05.033

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Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism

Energy, Resources and Environmental Technology | Updated：2026-01-06

- Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism
- Chinese Journal of Chemical Engineering Vol. 28, Issue 10, Pages: 2658-2667(2020)
- Affiliations：
  
  1. Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon,Hong Kong,China,999077
  2. Department of Chemistry, Government College University,Faisalabad,Pakistan,38000
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.05.033
  CLC：
- Published：2020
- Accepted：
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Muhammad Imran Kanjal, Majid Muneer, Amal Abdelhaleem, Wei Chu. Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2658-2667.
DOI：

Muhammad Imran Kanjal, Majid Muneer, Amal Abdelhaleem, Wei Chu. Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2658-2667. DOI： 10.1016/j.cjche.2020.05.033.

摘要

Abstract

Methotrexate (MTX) is one of the most consumed anti-cancer drugs in the pharmaceutical market around the world. The widespread occurrence of MTX in aquatic environment through hospital effluent has attracted increasing concern due to its potential to induce water pollution. In the present study

the degradation of MTX in aqueous medium was investigated by UV-activated peroxymonosulfate (PMS). A significant improvement in degradation rate by increasing UV intensity and PMS concentration while the decrease in degradation efficiency with the increase of solution pH and initial concentration of MTX was observed. The proposed UV/PMS process could achieve more than 90% MTX degradation in 30 min with a good mineralization degree (65%). A pseudofirst order kinetic model was employed and successfully predicted the degradation of MTX. The effect of other operational parameters such as the initial concentration of the targeted compound

dosage of oxidant (PMS)

solution pH and UV intensity on the degradation rate were investigated. At the last

the main transform intermediates were identified using LC-MS and possible degradation pathways were proposed. The results show that UV/ PMS can be used as an efficient technology to treat pharmaceuticals such as methotrexate containing water and wastewater.

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