A safe and efficient process for the preparation of difluoromethane in continuous flow

Tao Shen; Xin Ge; Hengjun Zhao; Zhixiong Xu; Shaofeng Tong; Shaodong Zhou; Chao Qian; Xinzhi Chen

doi:10.1016/j.cjche.2020.02.024

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A safe and efficient process for the preparation of difluoromethane in continuous flow

Catalysis, Kinetics and Reaction Engineering | Updated：2026-01-06

- A safe and efficient process for the preparation of difluoromethane in continuous flow
- Chinese Journal of Chemical Engineering Vol. 28, Issue 7, Pages: 1860-1865(2020)
- Affiliations：
  
  1. College of Chemical and Biological Engineering, Zhejiang University, Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology,Hangzhou,China,310027
  2. School of Chemical and Material Engineering, Jiangnan University,Wuxi,China,214122
  3. Jiangsu Sanmei Chemical Co., Ltd.,Nantong,China,226461
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2020.02.024
  CLC：
- Published：2020
- Accepted：
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Tao Shen, Xin Ge, Hengjun Zhao, Zhixiong Xu, Shaofeng Tong, Shaodong Zhou, Chao Qian, Xinzhi Chen. A safe and efficient process for the preparation of difluoromethane in continuous flow[J]. Chinese Journal of Chemical Engineering, 2020, 28(7): 1860-1865.
DOI：

Tao Shen, Xin Ge, Hengjun Zhao, Zhixiong Xu, Shaofeng Tong, Shaodong Zhou, Chao Qian, Xinzhi Chen. A safe and efficient process for the preparation of difluoromethane in continuous flow[J]. Chinese Journal of Chemical Engineering, 2020, 28(7): 1860-1865. DOI： 10.1016/j.cjche.2020.02.024.

摘要

Abstract

Difluoromethane is typically produced

via

liquid-phase fluorination as performed in a batch reactor. However

this process suffers from some problems

e.g

severe corrosion of the reactor

high safety risk

and the regeneration of the catalyst. In this paper

a flow process as performed in the tubular reactor was designed. The optimum conditions for continuous synthesis of difluoromethane were obtained as follows: the reaction temperature was 100 ℃

the molar ratio of dichloromethane to hydrogen fluoride was 1.6:1 and the reaction time was 300 s. The operation of the cyclic process was stable for 24 h with the conversion per pass of hydrogen fluoride up to 16.2%. The unreacted raw materials were easily reused. The deactivation of the common catalyst

antimony pentachloride

was investigated by catalyst concentration curve and XPS analysis. The approach proposed in this work is proven to be safe

efficient and low amount of catalyst.

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