Synthesis and characterization of enzyme mimics with characteristic stability and high catalytic efficiency is an interesting field for researchers. Especially

with the development of nanoscience and introducing of Fe

3

O

4

magnetic nanoparticles as peroxidase mimics in 2007

various nanomaterials such as noble metals

metal oxides

and carbon materials were introduced as enzyme mimics (nanozymes). Various nanomaterials exhibit peroxidaselike activity

hence

most of the nanozymes are peroxidase mimetics. Although the nanozyme based sensors were previously classified

the classifications have been focused on the type of nanozyme action. Therefore

the nanozyme based sensors were classified as peroxidase

hydrolase

and urease mimic-based sensors. However

heretofore

these sensors are not classified based on the detection mechanism and principles of system design. The aim of this review is the focus on the peroxidase mimic based colorimetric sensors as the most common nanozyme-based sensors and their classification based on principles of sensor design and review of the detection mechanism of the current mimic peroxidase based sensors. Moreover

some current challenges and future developments in thi

s field are discussed.