Hollow MnO<sub>2</sub>/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Zheng Zhang; Yuanhui Ji; Wei Chen

doi:10.1016/j.cjche.2019.12.013

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Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Materials and Product Engineering | Updated：2026-01-06

- Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release
- Chinese Journal of Chemical Engineering Vol. 28, Issue 5, Pages: 1405-1414(2020)
- Affiliations：
  
  1. Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University,Jiangsu Province,Nanjing,China,211189
  2. Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University,Nanjing,China,210009
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2019.12.013
  CLC：
- Published：2020
- Accepted：
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/GNPs serving as a multiresponsive nanocarrier for controlled drug release[J]. 中国化学工程学报, 2020, 28(5): 1405-1414.
DOI：

/GNPs serving as a multiresponsive nanocarrier for controlled drug release[J]. 中国化学工程学报, 2020, 28(5): 1405-1414. DOI： 10.1016/j.cjche.2019.12.013.

摘要

Abstract

In this work

hollow manganese dioxide/gold nanoparticle (MnO

/GNPs) hybrid drug nanocarriers were prepared by coupling the gold nanoparticles (GNPs) with hollow structure manganese dioxide (MnO

). Among them

GNPs have been used as near-infrared (NIR)-responsive element for photothermal effect under NIR laser irradiation. The glutathione (GSH)-responsive and pH-responsive performances of drug release were derived from hollow MnO

. Particularly

Doxorubicin hydrochloride (DOX) can be loaded into hollow MnO

/GNPs with the drug loading efficiency up to 82.0%. Moreover

the photothermal effect and GSH-/pH-responsive properties of hollow MnO

/GNPs were investigated. The hollow MnO

/GNPs possessed satisfactory drug release efficiency (

. 87.4% of loaded drug released in 12 h) and have high photothermal conversion efficiency

multiresponsive properties

and degradability. Finally

the kinetics of drug release was discussed in detail. Thus

our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.

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Related Institution

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⁰

Hollow MnO2/GNPs serving as a multiresponsive nanocarrier for controlled drug release

DOI：10.1016/j.cjche.2019.12.013

摘要

Abstract

关键词

Keywords

references

Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release