Interactions of ciprofloxacin hydrochloride (CPFH) with sodium dodecyl sulfate (SDS) were investigated by conductivity measurement in H

2

O/electrolyte solutions (NaCl

Na

2

SO

4

Na

3

PO

4

) over 298.15-318.15 K temperature range (with 5 K interval) considering the human body temperature. In all cases

two critical micelle concentrations (

c

*

) were observed which are increased in the presence of drug and decreased in the presence of salts enunciating the presence of interaction amongst the studied components. For (CPFH+SDS) system in the presence of salt

the

c

*

values at 303.15

K

and

I

=0.50 mmol·kg

-1

followed the order:

C

NaCl

C

Na2SO4

C

Na3PO4

. The

G

1

m

0

and Δ

G

2

m

0

values are found to be negative for all systems that show that the micellization process is thermodynamically spontaneous. For (CPFH+SDS) system in water

the Δ

H

m

0

Δ

S

m

0

values reveal that the micellization proces

ses is both entropy dominated in almost all cases. In the occurrence of electrolytes

Δ

H

m

0

and Δ

S

m

0

values indicate that micellization processes are both entropy enthalpy restricted at upper temperature but it becomes totally entropy dependent at higher temperature. The higher positive Δ

S

m

0

values indicate the enhanced hydrophobic interaction in presence of salts. The enthalpy-entropy compensation was determined from the linear relationship between Δ

H

m

0

and Δ

S

m

0

values in every state. Different transfer energies as well as compensation temperature and intrinsic enthalpy were also evaluated and the behaviors were comparable to other biological system.