Experimental study and simulation of a three-phase flow stirred bioreactor

Chenghui Zheng; Jiashun Guo; Chengkai Wang; Yuanfeng Chen; Huidong Zheng; Zuoyi Yan; Qinggen Chen

doi:10.1016/j.cjche.2018.06.010

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Experimental study and simulation of a three-phase flow stirred bioreactor

Biotechnology and Bioengineering | Updated：2026-01-06

- Experimental study and simulation of a three-phase flow stirred bioreactor
- Chinese Journal of Chemical Engineering Vol. 27, Issue 3, Pages: 649-659(2019)
- Affiliations：
  
  1. 2 Fujian Provincial Academy of Environmental Science,Fuzhou,China,350013
  2. 3 Xiamen Zijin Mining & Metallurgy Technology Co. Ltd.,Xiamen,China,361102
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2018.06.010
  CLC：
- Published：2019
- Accepted：
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Chenghui Zheng, Jiashun Guo, Chengkai Wang, Yuanfeng Chen, Huidong Zheng, Zuoyi Yan, Qinggen Chen. Experimental study and simulation of a three-phase flow stirred bioreactor[J]. Chinese Journal of Chemical Engineering, 2019, 27(3): 649-659.
DOI：

Chenghui Zheng, Jiashun Guo, Chengkai Wang, Yuanfeng Chen, Huidong Zheng, Zuoyi Yan, Qinggen Chen. Experimental study and simulation of a three-phase flow stirred bioreactor[J]. Chinese Journal of Chemical Engineering, 2019, 27(3): 649-659. DOI： 10.1016/j.cjche.2018.06.010.

摘要

Abstract

In order to obtain the reasonable operating conditions and minimize the power consumption in the stirred bioreactor

the hydrodynamic experiments in the stirred bioreactor have been taken to obtain the basic data. Subsequently

an Eulerian model for the gas-liquid-solid three phase flow in the stirred bioreactor has been proposed and the CFD simulation has been conducted. By comparing the results of experiment and simulation

it can be concluded that the simulation results were consistent with the experimental data. The inner relationship between operating variables and indicators could be obtained by comparing the results of just suspension speed

gas holdup

power consumption and operational maps

further the reasonable operating conditions could be also determined under the minimum power consumption. The operational maps could provide the theoretical foundation for industrial application of the gas-liquid-solid stirred bioreactors under the low solid concentration (no more than 20 wt%).

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